|
| | Celiprolol Basic information |
| Product Name: | Celiprolol | | Synonyms: | celiptolol;-diethyl-;n’-(3-acetyl-4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)phenyl)-n,n-di;3-[3-acetyl-4-(2-hydroxy-3-tert-butylamino-propoxy)-phenyl]-1,1-diethyl-urea;CELIPROLOL;Celiprolol Base;CELIPROLOLHYDROCHLORIDE(SUBJECTTOPANTENTFREE);(R,S)-Celiprolol | | CAS: | 56980-93-9 | | MF: | C20H33N3O4 | | MW: | 379.49 | | EINECS: | 260-497-7 | | Product Categories: | | | Mol File: | 56980-93-9.mol |  |
| | Celiprolol Chemical Properties |
| Melting point | 110-112° | | Boiling point | 586.5±50.0 °C(Predicted) | | density | 1.114±0.06 g/cm3(Predicted) | | storage temp. | -20°C Freezer, Under Inert Atmosphere | | solubility | Chloroform (slightly), Methanol (Slightly) | | pka | pKa ～9.7 (Uncertain) | | form | Solid | | color | Yellow | | Water Solubility | 22.9mg/L(22.5 ºC) | | CAS DataBase Reference | 56980-93-9(CAS DataBase Reference) |
| | Celiprolol Usage And Synthesis |
| Originator | Selectol,Chemie Linz,Austria,1983 | | Uses | Celiprolol is an intermediate in the synthesis of Celiprolol Hydrochloride (C254500). Celiprolol is a cardioselective β1-adrenergic blocker. Antihypertensive, antianginal. | | Definition | ChEBI: 3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea is an aromatic ketone. | | Manufacturing Process | 3-Acetyl-4-hydroxyaniline, in solution in pyridine, is reacted with
dimethylcarbamoyl chloride at room temperature to give N-(3-acetyl-4-
hydroxy)phenyl-N'-dimethylurea, which after evaporating the pyridine, taking
up the residue in chloroform and evaporating the latter, is obtained in a
crystalline form. Melting point: 160°-162°C. After reaction of the product in
alkaline aqueous solution, with epichlorohydrin, N-[3-acetyl-4-(2',3'-epoxy)-
propoxy]-phenyl-N'-dimethylurea (melting point: 98°-102°C) is obtained, and
this, in turn, is reacted with excess tert-butylamine in aqueous solution at
room temperature to give N-[3-acetyl-4-(3'-tert-butylamino-2'-hydroxy)-
propoxy)-phenyl-N'-dimethylurea of melting point: 120°-122°C. | | Therapeutic Function | Beta-adrenergic blocker |
| | Celiprolol Preparation Products And Raw materials |
|
