A 205804

A 205804 Basic information
Product Name:A 205804
Synonyms:A 205804;4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide;A 205804,4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxaMide;4-(p-tolylthio)thieno[2,3-c]pyridine-2-carboxamide;Thieno[2,3-c]pyridine-2-carboxamide, 4-[(4-methylphenyl)thio]-;4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide A-205804;IKK-16 (IKK Inhibitor VII);A-205804;A 205804
CAS:251992-66-2
MF:C15H12N2OS2
MW:300.4
EINECS:
Product Categories:Inhibitors
Mol File:251992-66-2.mol
A 205804 Structure
A 205804 Chemical Properties
Melting point 198-199℃
Boiling point 581.3±45.0 °C(Predicted)
density 1.40±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility ≥30 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form powder to crystal
pka15.12±0.30(Predicted)
color White to Orange to Green
Safety Information
HS Code 2934.99.9001
MSDS Information
A 205804 Usage And Synthesis
DescriptionA-205804 is a potent inhibitor of E-selectin and ICAM-1 expression in human vascular endothelial cells stimulated with TNF-α (IC50s = 20 and 25 nM, respectively). It does not block expression of VCAM-1 (IC50 > 1,000 nM).
Uses4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide is a reagent used in the preparation of selective inhibitors of cell adhesion molecule expression in human endothelial cells.
DefinitionChEBI: 4-[(4-methylphenyl)thio]-2-thieno[2,3-c]pyridinecarboxamide is an aryl sulfide.
Biological ActivitySelective inhibitor of E-selectin and ICAM-1 expression (IC 50 values are 20, 25 and > 1000 nM for TNF- α -induced E-selectin, ICAM-1 and VCAM-1 expression respectively). Effective inhibitor of cell-cell adhesion in an in vitro flow experiment.
storageStore at +4°C
references[1]. stewart, a.o., et al., discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. selective inhibition of icam-1 and e-selectin expression. j med chem, 2001. 44(6): p. 988-1002.
[2]. chang, c.z., et al., valproic acid attenuates intercellular adhesion molecule-1 and e-selectin through a chemokine ligand 5 dependent mechanism and subarachnoid hemorrhage induced vasospasm in a rat model. j inflamm (lond), 2015. 12: p. 27.
[3]. zhu, g.d., et al., selective inhibition of icam-1 and e-selectin expression in human endothelial cells. 2. aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at c-2 carbamides. j med chem, 2001. 44(21): p. 3469-87.
[4]. zhu, g.d., et al., synthesis and mode of action of (125)i- and (3)h-labeled thieno[2,3-c]pyridine antagonists of cell adhesion molecule expression. j org chem, 2002. 67(3): p. 943-8.
A 205804 Preparation Products And Raw materials
PLX4032 TAK875 Poly(methyl methacrylate) Raltitrexed p-Tolualdehyde Benzyl alcohol 2-Methylpropanedioic acid 4'-Hydroxyacetophenone Nintedanib Ki16198 (S)-(+)-Benzyl glycidyl ether Selumetinib p-Toluenethiol Thieno[2,3-c]pyridine, 2-methyl- (9CI) A 205804

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