ChemicalBook Product Catalog API Circulatory system drugs Antiarrhythmics Drugs Indeloxazine hydrochloride

Indeloxazine hydrochloride

Indeloxazine hydrochloride Basic information
Product Name:Indeloxazine hydrochloride
Synonyms:MORPHOLINE, 2-[(1H-INDEN-7-YLOXY)METHYL]-, HYDROCHLORIDE;Indeloxazine hydrochloride;CI 874;Elen;Noin;YM 08054;YM 08054-1;(±)-2-[(1H-Inden-7-yloxy)methyl]morpholine hydrochloride
CAS:65043-22-3
MF:C14H18ClNO2
MW:267.75
EINECS:
Product Categories:
Mol File:65043-22-3.mol
Indeloxazine hydrochloride Structure
Indeloxazine hydrochloride Chemical Properties
Melting point 169-170°; mp 155-156°
storage temp. Sealed in dry,Room Temperature
Safety Information
RIDADR 3249
HazardClass 6.1(b)
PackingGroup III
ToxicityLD50 in mice (mg/kg): 47 i.v. (Tachikawa)
MSDS Information
Indeloxazine hydrochloride Usage And Synthesis
DescriptionIndeloxazine hydrochloride is a nootropic indicated for the treatment of senile dementia. In animal models indeloxazine reportedly enhances brain energy metabolism and monoamine content; its claimed protective effect on ischemia-induced amnesia is supported by the prolonged step-through latency in passive avoidance tests.
OriginatorYamanouchi (Japan)
UsesAntidepressant.
Brand nameElen
Metabolic pathwayAfter oral administration of indeloxazine hydrochloride to rats, two conjugates, which are labile to a- glucosidase hydrolysis but refractory to b-glucosidase, are isolated from the urine and identified as a-D- glucopyranosides of trans-4-(2-morpholinylmethoxy)- 1,2-indandiol and trans-6-[[(1,2-dihydroxy-4- indanyl)oxy]-methyl]-3-morpholinone.
Indeloxazine hydrochloride Preparation Products And Raw materials
Raw materialsMagnesium sulfate-->Isopropyl alcohol-->Indene-->2-AMINOETHYL HYDROGEN SULFATE-->Expoxide
2-Hydroxymethylmorpholine morpholine Naloxone hydrochloride 3-(3-METHYLPHENOXY)PROPAN-1-AMINE HYDROCHLORIDE 7-HYDROXYINDENE Moroxydine hydrochloride 1-(2-ALLYL-PHENOXY)-3-METHYLAMINO-PROPAN-2-OL Moroxydine Topotecan hydrochloride Tamsulosin hydrochloride Indeloxazine hydrochloride 2-Methylmorpholine 2-PHENOXYMETHYL-MORPHOLINE (RS)-N-Methyl-gama-(1-naphthalenyloxy)-2-thiophenepropanamine hydrochloride Loperamide hydrochloride Indeloxazine Dimethomorph
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