Human disease caused by the infection of parasitic worm is called helminthiasis. Worms include tapeworms, nematodes and trematodes. The WHO estimates that nearly 20 million people around the world are infected by a worm, which has a serious impact on human health and the development of social economy. In recent years, people developed a number of broad-spectrum, efficient and safe anti-worm drugs such as albendazole, mebendazole, etc., to replace the traditional anthelmintic such as santonin and hexylresorcinol. The cure rate of praziquantel for schistosomiasis is up to 90%. Diethylcarbamazine is an effective anti-filariasis drug.