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| | AROTINOLOL HCL Basic information |
| Product Name: | AROTINOLOL HCL | | Synonyms: | thiazolehcl;2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-, monohydrochloride;2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-, monohydrochloride, (+-)-;Almarl;ARL;(+-)-2-(3'-tert-Butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'-thienyl)thiazole HCl;Acemail;Anasirol | | CAS: | 68377-91-3 | | MF: | C15H22ClN3O2S3 | | MW: | 408 | | EINECS: | | | Product Categories: | API | | Mol File: | 68377-91-3.mol |  |
| | AROTINOLOL HCL Chemical Properties |
| Melting point | 234-235.5° (dec) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | Water Solubility | Practically insoluble in water | | form | powder to crystal | | color | White to Orange to Green | | Merck | 14,791 |
| RIDADR | UN 2811 6.1/PG III | | RTECS | XM8301000 | | HS Code | 2934.99.3000 | | HazardClass | 6.1 | | PackingGroup | III | | Toxicity | LD50 in mice (mg/kg): 86 i.v., >360 i.p., >5000 orally (Hara) |
| | AROTINOLOL HCL Usage And Synthesis |
| Description | Arotinolol hydrochloride i s a β-adrenergic
blocker with weak
α-antagonistic properties,
useful in the treatment of hypertension. | | Originator | Sumitomo (Japan) | | Uses | Arotinolol is both and alpha- and beta-adrenoceptor antagonist and is used to treat essential tremors and hypertension. | | Definition | ChEBI: Arotinolol hydrochloride is an aromatic amide and a member of thiophenes. | | Manufacturing Process | To a solution of 2-mercapto-4-(5'-carbamoyl-2'-thiophenyl)thiazole, 3.2 g in
20 ml of 0.3 % aqueous sodium hydroxide solution, 1-chloro-3-tbutylaminopropanol,
12.64 g in 20 ml of methanol was added, while the
temperature was maintained at 20°C.
The reaction solution was stirred at room temperature for 4 h, and then
condensed to a half volume in vacuo. The residual solution, added with 100 ml
of water, was extracted with chloroform. The chloroform extract was washed
with water, dried over anhydrous magnesium sulfate and evaporated in vacuo
to give 4.8 g of 2-(3'-t-butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'-
thiophenyl)thiazole, as crystals, melting point 234°-235.5°C (dec.,
recrystallized from methanol/water).
In practice it is usually used as hydrochloride. | | Brand name | ALMARL | | Therapeutic Function | Beta-adrenergic blocker |
| | AROTINOLOL HCL Preparation Products And Raw materials |
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