6-aminocarbovir

6-aminocarbovir Basic information
Product Name:6-aminocarbovir
Synonyms:(1α,4α)-4-(2,6-Diamino-9H-purin-9-yl)-2-cyclopentenyl-carbinol;Abacavir Impurity 3(Abacavir EP Impurity C);(Abacavir EP Impurity C);Abacavir Related CoMpound A;6-aminocarbovir;(-)-2,6-Diamino-9-[(1R)-4β-(hydroxymethyl)-2-cyclopentene-1β-yl]-6,9-dihydro-1H-purine;2-Cyclopentene-1-methanol, 4-(2,6-diamino-9H-purin-9-yl)-, (1S-cis)-;Descyclopropyl Abacavir
CAS:124752-25-6
MF:C11H14N6O
MW:246.27
EINECS:
Product Categories:Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
Mol File:124752-25-6.mol
6-aminocarbovir Structure
6-aminocarbovir Chemical Properties
Melting point 180-182°C
Boiling point 628.2±65.0 °C(Predicted)
density 1.75±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility DMSO (Slightly), Methanol (Slightly, Heated)
pka14.86±0.10(Predicted)
form neat
color Off-White to Pale Yellow
Safety Information
Hazard Codes Xi
Risk Statements 41-43
Safety Statements 26-36/37-39
HS Code 2933599550
MSDS Information
6-aminocarbovir Usage And Synthesis
Chemical PropertiesOff-White to Pale Yellow Solid
UsesDescyclopropyl Abacavir (Abacavir EP Impurity C; Abacavir Related Compound A) is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
UsesAbacavir Intermediate.
6-aminocarbovir Preparation Products And Raw materials
Abacavir 2,6-Diaminopurine Abacavir Related CoMpound D Abacavir Carboxylate Abacavir (1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride 2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1R-cis)- (1R,3S)-3-[2-AMino-6-(cyclopropylaMino)-9H-purin-9-yl]cyclopentaneMethanol Abacavir sulfate Abacavir Clorabacavir racemic trans-Abacavir Hydrochloride Abacavir Impurity 6 Abacavir Impurity 1 Abacavir Impurity A Abacavir Abacavir 5'-Glucuronide 2-Amino-6-cyclopropylamino-9H-purine

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