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| | 6-aminocarbovir Basic information |
| Product Name: | 6-aminocarbovir | | Synonyms: | (1α,4α)-4-(2,6-Diamino-9H-purin-9-yl)-2-cyclopentenyl-carbinol;Abacavir Impurity 3(Abacavir EP Impurity C);(Abacavir EP Impurity C);Abacavir Related CoMpound A;6-aminocarbovir;(-)-2,6-Diamino-9-[(1R)-4β-(hydroxymethyl)-2-cyclopentene-1β-yl]-6,9-dihydro-1H-purine;2-Cyclopentene-1-methanol, 4-(2,6-diamino-9H-purin-9-yl)-, (1S-cis)-;Descyclopropyl Abacavir | | CAS: | 124752-25-6 | | MF: | C11H14N6O | | MW: | 246.27 | | EINECS: | | | Product Categories: | Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals | | Mol File: | 124752-25-6.mol |  |
| | 6-aminocarbovir Chemical Properties |
| Melting point | 180-182°C | | Boiling point | 628.2±65.0 °C(Predicted) | | density | 1.75±0.1 g/cm3(Predicted) | | storage temp. | -20°C Freezer | | solubility | DMSO (Slightly), Methanol (Slightly, Heated) | | pka | 14.86±0.10(Predicted) | | form | neat | | color | Off-White to Pale Yellow |
| | 6-aminocarbovir Usage And Synthesis |
| Chemical Properties | Off-White to Pale Yellow Solid | | Uses | Descyclopropyl Abacavir (Abacavir EP Impurity C; Abacavir Related Compound A) is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. | | Uses | Abacavir Intermediate. |
| | 6-aminocarbovir Preparation Products And Raw materials |
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