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| | Antazoline Basic information |
| Product Name: | Antazoline | | Synonyms: | 1H-Imidazole-2-methanamine, 4,5-dihydro-N-phenyl-N-(phenylmethyl)-;2-(N-Phenyl-N-benzylaminomethyl)imidazoline;2-[(N-Benzylanilino)methyl]-2-imidazol;2-[(N-Benzylanilino)methyl]-2-imidazoline;2-Imidazoline, 2-[(N-benzylanilino)methyl]-;2-Phenyl-benzyl-amino-methylimidazolin;4,5-Dihydro-N-phenyl-N-phenylmethyl-1H-imidazole-2-methanamine;5512-M | | CAS: | 91-75-8 | | MF: | C17H19N3 | | MW: | 265.35 | | EINECS: | 202-094-0 | | Product Categories: | | | Mol File: | 91-75-8.mol |  |
| | Antazoline Chemical Properties |
| Melting point | 120-122° | | Boiling point | 398.57°C (rough estimate) | | density | 0.9786 (rough estimate) | | refractive index | 1.6080 (estimate) | | pka | pKa 6.65(H2O
t = 25
I = 0.05) (Uncertain) | | form | A solid | | Water Solubility | 663.4mg/L(30 ºC) | | CAS DataBase Reference | 91-75-8(CAS DataBase Reference) | | NIST Chemistry Reference | Antazoline(91-75-8) |
| | Antazoline Usage And Synthesis |
| Chemical Properties | White, odorless crystalline powder with bitter taste. Sparingly soluble in alcohol and water; practically insoluble in benzene and ether. | | Originator | Antistine HCl,Ciba,US,1948 | | Uses | Antihistaminic. | | Definition | ChEBI: A member of the class of imidazolines that is 2-aminomethyl-2-imidazoline in which the exocyclic amino hydrogens are replaced by benzyl and phenyl groups. Antazoline is only found in individuals that have taken the drug. | | Manufacturing Process | 15.4 parts of 2-chloromethylimidazoline hydrochloride, 45.8 parts of Nbenzylaniline
and 150 parts of alcohol are heated in an oil bath at 100° to
110°C. After distilling off the alcohol, the reaction mass is maintained at this
temperature for a further 3 hours and then triturated with water and 10 parts
of sodium bicarbonate. The unconsumed benzylaniline is extracted with ether
and the aqueous solution neutralized with dilute hydrochloric acid. By
evaporating this solution and extracting the residue with alcohol there is
obtained 2-(N-phenyl-N-benzylaminomethyl)imidazoline hydrochloride in the form of colorless crystals of melting point 227° to 229°C. | | Therapeutic Function | Antihistaminic | | Safety Profile | Poison by ingestion, subcutaneous, and intraperitoneal routes. An eye irritant. When heated to decomposition it emits toxic fumes of NOx. |
| | Antazoline Preparation Products And Raw materials |
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