ChemicalBook Product Catalog API Circulatory system drugs Antiarrhythmics Drugs N-ACETYLPROCAINAMIDE

N-ACETYLPROCAINAMIDE

N-ACETYLPROCAINAMIDE Basic information
Product Name:N-ACETYLPROCAINAMIDE
Synonyms:4-(acetylamino)-n-(2-(diethylamino)ethyl)-benzamid;4-(acetylamino)-n-[2-(diethylamino)ethyl]-benzamid;4-acetamido-N-(2-(diethylamino)ethyl)benzamide;4’-((2-(diethylamino)ethyl)carbamoyl)-acetanilid;4’-((2-(diethylamino)ethyl)carbamoyl)acetanilide;acecainide;acekainid;n-acetyloprokainamid
CAS:32795-44-1
MF:C15H23N3O2
MW:277.36
EINECS:
Product Categories:TINDAMAX;Amides;Carbonyl Compounds;Organic Building Blocks
Mol File:32795-44-1.mol
N-ACETYLPROCAINAMIDE Structure
N-ACETYLPROCAINAMIDE Chemical Properties
Melting point 138-140 °C(lit.)
Boiling point 500.0±35.0 °C(Predicted)
density 1.097±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility soluble1%, clear, colorless to faintly yellow (1N HCl)
pka14.54±0.46(Predicted)
Merck 13,20
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR 3249
WGK Germany 3
RTECS AE1974350
HazardClass 6.1(b)
PackingGroup III
MSDS Information
ProviderLanguage
SigmaAldrich English
N-ACETYLPROCAINAMIDE Usage And Synthesis
OriginatorAcecainide ,ZYF Pharm Chemical
Usesantiprotozoal
UsesN-acetylprocainamide (NAPA) was used as a model drug in the study of establishing a quantitative approach to predict the renal clearances of basic drugs using N-1-methylnicotinamide (NMN).
DefinitionChEBI: A benzamide obtained via formal condensation of 4-acetamidobenzoic acid and 2-(diethylamino)ethylamine.
Manufacturing Process1.0 g of p-amino-N-(2-diethylaminoethyl)benzamide is dissolved in chloroform. A few ice cubes are added to the solution. Acetyl chloride is added dropwise with stirring until no more white precipitate forms; the latter is separated by filtering under suction. The precipitate is washed with cold acetone and dried overnight in a vacuum oven at room temperature. The product is dissolved in a minimum amount of hot isopropanol and allowed to precipitate in the cold. The p-acetamido-N-(2-diethylaminoethyl)benzamide hydrochloride, is recrystallized a second time from hot isopropanol, melting point 190°-193°C. The free base is obtained from the hydrochloride by dissolving the latter in water, adjusting the pH to greater than 10 with dilute sodium hydroxide, and adding an equal volume of benzene. After shaking in a separatory funnel, the benzene layer is recovered and evaporated to dryness. So the p-acetamido-N- (2-diethylaminoethyl)benzamide is obtained.
Therapeutic FunctionAntiarrhythmic
General DescriptionThe relaxant effects of N-acetylprocainamide on bovine tracheal smooth muscle was studied.
N-ACETYLPROCAINAMIDE Preparation Products And Raw materials
Raw materialsSodium hydroxide-->Acetyl chloride
4-METHYLFORMANILIDE N1-BENZYL-N2-ETHYLETHANE-1,2-DIAMINE 4-Amino-N-methylbenzamide N-propionylprocainamide 4-Amino-N-methylbenzylamine 4-ACETAMIDOBENZYLAMINE 4-Acetamidobenzaldehyde p-Acetotoluidide 4-Aminobenzylamine N-{4-[(methylamino)methyl]phenyl}acetamide N-BENZYL-N'-METHYLETHYLENEDIAMINE procainamide N-Benzylethylenediamine N'-Benzyl-N,N-diethylethylenediamine N'-BENZYL-N,N-DIMETHYLETHYLENEDIAMINE N-ACETYLPROCAINAMIDE 4-METHYLAMINO-BENZAMIDE 4-AMINO-N-ETHYLBENZAMIDE
Email:[email protected] [email protected]
Copyright © 2025 Mywellwork.com All rights reserved.