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| | 2-Methylcyclohexanone Basic information |
| Product Name: | 2-Methylcyclohexanone | | Synonyms: | Cyclohexanone, 2-methyl-;METHYLCYCLOHEXANONE, 2-(SG);TETRAHYDRO-O-CRESOL;O-METHYLCYCLOHEXANONE;2-METHYLCYCLOHEXANONE 99+%;o-Methylcycloexanone;2-Methylcyclohexanone,98%;Cyclohexanone, 2-methyl- (8CI, 9CI) | | CAS: | 583-60-8 | | MF: | C7H12O | | MW: | 112.17 | | EINECS: | 209-513-6 | | Product Categories: | | | Mol File: | 583-60-8.mol |  |
| | 2-Methylcyclohexanone Chemical Properties |
| Melting point | -14 °C | | Boiling point | 162-163 °C (lit.) | | density | 0.924 g/mL at 25 °C (lit.) | | vapor pressure | 1 at 20 °C (NIOSH, 1997) | | refractive index | n20/D 1.448(lit.) | | FEMA | 3946 | 2-METHYLCYCLOHEXANONE | | Fp | 116 °F | | storage temp. | Sealed in dry,2-8°C | | solubility | Soluble in alcohol, ether (Weast, 1986), and many other polar organic solvents including
cyclohexanone. | | form | Liquid | | color | Clear colorless to very slightly yellow | | Odor | at 10.00 % in dipropylene glycol. minty peppermint cooling | | Odor Type | minty | | explosive limit | 1.2%(V) | | Water Solubility | Insoluble in water. Soluble in methanol and diethyl ether. | | JECFA Number | 1102 | | BRN | 506751 | | Exposure limits | TLV-TWA 230 mg/m3 (50 ppm) (ACGIH);
STEL 345 mg/m3 (75 ppm); IDLH 2500
ppm (NIOSH). | | InChIKey | LFSAPCRASZRSKS-UHFFFAOYSA-N | | LogP | 1.54 at 25℃ | | CAS DataBase Reference | 583-60-8(CAS DataBase Reference) | | NIST Chemistry Reference | Cyclohexanone, 2-methyl-(583-60-8) | | EPA Substance Registry System | 2-Methylcyclohexanone (583-60-8) |
| Hazard Codes | Xn | | Risk Statements | 10-20-20/21/22 | | Safety Statements | 25-36/37 | | RIDADR | UN 2297 3/PG 3 | | WGK Germany | 1 | | RTECS | GW1750000 | | TSCA | Yes | | HazardClass | 3 | | PackingGroup | III | | HS Code | 29142200 | | Hazardous Substances Data | 583-60-8(Hazardous Substances Data) | | Toxicity | Acute oral LD50 for rats 2,140 mg/kg, rabbits 1 g/kg (quoted, RTECS, 1985). | | IDLA | 600 ppm |
| | 2-Methylcyclohexanone Usage And Synthesis |
| Chemical Properties | CLEAR COLOURLESS TO VERY SLIGHTLY YELLOW LIQUID | | Chemical Properties | o-Methylcyclohexanone is a colorless liquid
with a weak peppermint-like odor (also reported to be
acetone-like). | | Chemical Properties | 2-Methylcyclohexanone has a weak, peppermint odor and burning sensation | | Physical properties | Colorless liquid with a weak, peppermint-like odor. | | Occurrence | Reported found in cockroaches as attractant pheromone; not reported found in natural foods | | Uses | Solvent; rust remover | | Uses | o-Methyl cyclohexanone is used as a solventfor varnishes, lacquers, and plastics; and asa rust remover. | | Uses | 2-Methylcyclohexanone can be used as solvent, lacquers.
| | Preparation | From cyclohexanone by treatment with a base and then with methyl iodide | | Production Methods | 2-Methylcyclohexanone is manufactured by the catalytic
hydrogenation of o-cresol or by the dehydrogenation of
o-methylcyclohexanol. Methylcyclohexanones are
used in small amounts as general purpose solvents for
cellulose-based finishes and coatings. | | Synthesis Reference(s) | Journal of the American Chemical Society, 108, p. 304, 1986 DOI: 10.1021/ja00262a025
Synthetic Communications, 8, p. 9, 1978 DOI: 10.1080/00397917808062176
Synthesis, p. 611, 1976 DOI: 10.1055/s-1976-24139 | | General Description | A water-white to pale yellow liquid with an acetone-like odor. Less dense than water. Vapors heavier than air. Flash point near 135°F. May be toxic by ingestion. Used as a solvent. | | Air & Water Reactions | Flammable. Slightly soluble in water. | | Reactivity Profile | Contact with strong oxidizers may cause fires and explosions [USCG, 1999]. | | Hazard | Moderate fire risk. Toxic by ingestion,inhalation, and skin absorption. Eye and upper res-piratory tract irritant, and central nervous systemimpairment. | | Health Hazard | May cause irritation of the eyes, nose and throat. Prolonged or repeated contact may cause dermatitis. | | Health Hazard | o-Methyl cyclohexanone is a mildly toxiccompound. Any health hazard from inhalingits vapors is low. Its vapors at highconcentrations in air can be irritating to theeyes, nose, and throat. Ingestion of the liquidcan cause sleepiness. Toxicity studies on animalssuggest that methyl cyclohexanone maycause an adverse effect on the lungs, kidney,and liver. An intravenous administration of270 mg/kg was lethal to mice.
LD50 value, intraperitoneal (mice): 200mg/kg. | | Fire Hazard | Special Hazards of Combustion Products: Irritating vapors and toxic gases, such as carbon monoxide, may be formed when involved in fire. | | Flammability and Explosibility | Flammable | | Safety Profile | Poison by
intraperitoneal route. Moderately toxic by
ingestion and skin contact. When heated to
decomposition it emits acrid smoke and
irritating fumes. | | Potential Exposure | Methylcyclohexanone is used as a solvent in making varnish, plastics, and as a rust remover.
Also used in the leather industry. | | Shipping | UN2297 Methylcyclohexanone, Hazard Class: 3;
Labels: 3-Flammable liquid. | | Incompatibilities | Vapors may form explosive mixture with
air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep
away from alkaline materials, strong bases, strong acids,
oxoacids, epoxides. Contact with peroxides may form
unstable heat- and shock-sensitive explosives | | Waste Disposal | Dissolve or mix the material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All
federal, state, and local environmental regulations must
be observed |
| | 2-Methylcyclohexanone Preparation Products And Raw materials |
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