2-Methylcyclohexanone

2-Methylcyclohexanone Basic information
Product Name:2-Methylcyclohexanone
Synonyms:Cyclohexanone, 2-methyl-;METHYLCYCLOHEXANONE, 2-(SG);TETRAHYDRO-O-CRESOL;O-METHYLCYCLOHEXANONE;2-METHYLCYCLOHEXANONE 99+%;o-Methylcycloexanone;2-Methylcyclohexanone,98%;Cyclohexanone, 2-methyl- (8CI, 9CI)
CAS:583-60-8
MF:C7H12O
MW:112.17
EINECS:209-513-6
Product Categories:
Mol File:583-60-8.mol
2-Methylcyclohexanone Structure
2-Methylcyclohexanone Chemical Properties
Melting point -14 °C
Boiling point 162-163 °C (lit.)
density 0.924 g/mL at 25 °C (lit.)
vapor pressure 1 at 20 °C (NIOSH, 1997)
refractive index n20/D 1.448(lit.)
FEMA 3946 | 2-METHYLCYCLOHEXANONE
Fp 116 °F
storage temp. Sealed in dry,2-8°C
solubility Soluble in alcohol, ether (Weast, 1986), and many other polar organic solvents including cyclohexanone.
form Liquid
color Clear colorless to very slightly yellow
Odorat 10.00 % in dipropylene glycol. minty peppermint cooling
Odor Typeminty
explosive limit1.2%(V)
Water Solubility Insoluble in water. Soluble in methanol and diethyl ether.
JECFA Number1102
BRN 506751
Exposure limitsTLV-TWA 230 mg/m3 (50 ppm) (ACGIH); STEL 345 mg/m3 (75 ppm); IDLH 2500 ppm (NIOSH).
InChIKeyLFSAPCRASZRSKS-UHFFFAOYSA-N
LogP1.54 at 25℃
CAS DataBase Reference583-60-8(CAS DataBase Reference)
NIST Chemistry ReferenceCyclohexanone, 2-methyl-(583-60-8)
EPA Substance Registry System2-Methylcyclohexanone (583-60-8)
Safety Information
Hazard Codes Xn
Risk Statements 10-20-20/21/22
Safety Statements 25-36/37
RIDADR UN 2297 3/PG 3
WGK Germany 1
RTECS GW1750000
TSCA Yes
HazardClass 3
PackingGroup III
HS Code 29142200
Hazardous Substances Data583-60-8(Hazardous Substances Data)
ToxicityAcute oral LD50 for rats 2,140 mg/kg, rabbits 1 g/kg (quoted, RTECS, 1985).
IDLA600 ppm
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
2-Methylcyclohexanone Usage And Synthesis
Chemical PropertiesCLEAR COLOURLESS TO VERY SLIGHTLY YELLOW LIQUID
Chemical Propertieso-Methylcyclohexanone is a colorless liquid with a weak peppermint-like odor (also reported to be acetone-like).
Chemical Properties2-Methylcyclohexanone has a weak, peppermint odor and burning sensation
Physical propertiesColorless liquid with a weak, peppermint-like odor.
OccurrenceReported found in cockroaches as attractant pheromone; not reported found in natural foods
UsesSolvent; rust remover
Useso-Methyl cyclohexanone is used as a solventfor varnishes, lacquers, and plastics; and asa rust remover.
Uses2-Methylcyclohexanone can be used as solvent, lacquers.
PreparationFrom cyclohexanone by treatment with a base and then with methyl iodide
Production Methods2-Methylcyclohexanone is manufactured by the catalytic hydrogenation of o-cresol or by the dehydrogenation of o-methylcyclohexanol. Methylcyclohexanones are used in small amounts as general purpose solvents for cellulose-based finishes and coatings.
Synthesis Reference(s)Journal of the American Chemical Society, 108, p. 304, 1986 DOI: 10.1021/ja00262a025
Synthetic Communications, 8, p. 9, 1978 DOI: 10.1080/00397917808062176
Synthesis, p. 611, 1976 DOI: 10.1055/s-1976-24139
General DescriptionA water-white to pale yellow liquid with an acetone-like odor. Less dense than water. Vapors heavier than air. Flash point near 135°F. May be toxic by ingestion. Used as a solvent.
Air & Water ReactionsFlammable. Slightly soluble in water.
Reactivity ProfileContact with strong oxidizers may cause fires and explosions [USCG, 1999].
HazardModerate fire risk. Toxic by ingestion,inhalation, and skin absorption. Eye and upper res-piratory tract irritant, and central nervous systemimpairment.
Health HazardMay cause irritation of the eyes, nose and throat. Prolonged or repeated contact may cause dermatitis.
Health Hazardo-Methyl cyclohexanone is a mildly toxiccompound. Any health hazard from inhalingits vapors is low. Its vapors at highconcentrations in air can be irritating to theeyes, nose, and throat. Ingestion of the liquidcan cause sleepiness. Toxicity studies on animalssuggest that methyl cyclohexanone maycause an adverse effect on the lungs, kidney,and liver. An intravenous administration of270 mg/kg was lethal to mice.
LD50 value, intraperitoneal (mice): 200mg/kg.
Fire HazardSpecial Hazards of Combustion Products: Irritating vapors and toxic gases, such as carbon monoxide, may be formed when involved in fire.
Flammability and ExplosibilityFlammable
Safety ProfilePoison by intraperitoneal route. Moderately toxic by ingestion and skin contact. When heated to decomposition it emits acrid smoke and irritating fumes.
Potential ExposureMethylcyclohexanone is used as a solvent in making varnish, plastics, and as a rust remover. Also used in the leather industry.
ShippingUN2297 Methylcyclohexanone, Hazard Class: 3; Labels: 3-Flammable liquid.
IncompatibilitiesVapors may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Contact with peroxides may form unstable heat- and shock-sensitive explosives
Waste DisposalDissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed
2-Methylcyclohexanone Preparation Products And Raw materials
Preparation Products2,2-DIMETHYLCYCLOHEXANONE-->CIS-2-METHYLCYCLOHEXANOL-->TRANS-2-METHYLCYCLOHEXANOL-->3-METHYLCYCLOHEXANE-1,2-DIONE-->1-Methylcyclohexanol-->Cyclohexanol, 2-methyl-1-(4-methylphenyl)-
2-ACETYL-1,3-CYCLOHEXANEDIONE Adrenosterone 2,5-dioxo-1,4-cyclohexanedicarboxylic acid dimethyl ester ALPHA-(-)-THUJONE 2-Methyl-1,3-cyclohexanedione 11-KETOANDROSTERONE 2,5-DIMETHYLCYCLOHEXANONE 2-ACETYLCYCLOHEXANONE 2-Methylcyclohexanone Diethyl succinosuccinate (R)-(+)-2-(2'-CARBOMETHOXYETHYL)-2-METHYLCYCLOHEXANONE,R(+)-2-(2-CARBOMETHOXYETHYL)-2-METHYLCYCLOHEXANONE Ethyl 2-oxocyclohexanecarboxylate 2-(3-METHOXYPHENYL)CYCLOHEXANONE 3-(HEPTAFLUOROBUTYRYL)-I-CAMPHOR ETHYL 4-METHYL-2-CYCLOHEXANONE-1-CARBOXYLATE (2R,5R)-5-ISOPROPENYL-2-METHYLCYCLOHEXANONE (+)-Camphor Bromide ETHYL 2-CYCLOHEXANONEACETATE

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.