2-Amino-4-chlorophenol

2-Amino-4-chlorophenol Basic information

Product Name:	2-Amino-4-chlorophenol
Synonyms:	2-amino-4-chloro-pheno;2-Hydroxy-5-chloroaniline;2-AMINO-4-CHLOROPHENOL FOR SYNTHESIS;2-AMino-4-chlorophenol, 97% 100GR;C.I. 76525;C.I. Oxidation Base 18;c.i.76525;c.i.oxidationbase18
CAS:	95-85-2
MF:	C6H6ClNO
MW:	143.57
EINECS:	202-458-9
Product Categories:	Dyestuff Intermediates;Building Blocks;C6 to C8;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Anilines, Aromatic Amines and Nitro Compounds;Phenoles and thiophenoles;Dye Intermediate;Phenols
Mol File:	95-85-2.mol

2-Amino-4-chlorophenol Chemical Properties

Melting point	136-141 °C(lit.)
Boiling point	185.5°C (rough estimate)
density	1.2028 (rough estimate)
refractive index	1.5618 (estimate)
storage temp.	2-8°C
solubility	2.3g/l
pka	9.31±0.18(Predicted)
form	Solid
Colour Index	76525
color	Pale Orange to Light Brown
Water Solubility	Insoluble. <0.1 g/100 mL at 20 ºC
BRN	774859
Stability:	Stable. Incompatible with strong oxidizing agents.
InChIKey	SWFNPENEBHAHEB-UHFFFAOYSA-N
CAS DataBase Reference	95-85-2(CAS DataBase Reference)
IARC	2B (Vol. 123) 2020
NIST Chemistry Reference	5-Chloro-2-hydroxyaniline(95-85-2)
EPA Substance Registry System	2-Amino-4-chlorophenol (95-85-2)

Safety Information

Hazard Codes	Xn
Risk Statements	22-36/37/38-20/21/22
Safety Statements	26-36-36/37/39
RIDADR	UN 2673 6.1/PG 2
WGK Germany	3
RTECS	SJ5700000
TSCA	Yes
HazardClass	6.1
PackingGroup	II
HS Code	29222900

MSDS Information

Provider	Language
5-Chloro-2-hydroxyaniline	English
SigmaAldrich	English
ACROS	English
ALFA	English

2-Amino-4-chlorophenol Usage And Synthesis

Chemical Properties	2-Amino-4-chlorophenol is a grayish to light brown crystalline solid or powder
Uses	Intermediate.
Uses	2-Amino-4-chlorophenol is a widely used reagent in the synthesis of various drugs, dyes and pesticides. A reagent in the synthesis of aggrecanase-2 inhibitors based on acylthiosemicarbazide zinc-binding, used in the treatment of osteoarthritis.
General Description	5-Chloro-2-hydroxyaniline is a light brown colored crystalline solid. 5-Chloro-2-hydroxyaniline may be toxic by ingestion. 5-Chloro-2-hydroxyaniline is insoluble in water. 5-Chloro-2-hydroxyaniline is used to make other chemicals.
Air & Water Reactions	5-Chloro-2-hydroxyaniline may be sensitive to prolonged exposure to air and/or light. Insoluble in water.
Reactivity Profile	5-Chloro-2-hydroxyaniline may react with strong oxidizing agents.
Health Hazard	Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard	Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways.
Safety Profile	A poison. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx. See also AROMATIC MINES and CHLORIDES.
Potential Exposure	Used as a chemical raw material, especially in dye manufacture
Shipping	UN2673 2-Amino-4-chlorophenol, Hazard Class: 6.1; Labels: 6.1-Poisonous materials
Incompatibilities	Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, iron, moisture and temperatures .43 C.

2-Amino-4-chlorophenol Preparation Products And Raw materials

Raw materials

4-CHLORO-2-NITROPHENOL-->chloroazobenzene

Preparation Products

Neutral Red 2gl-->1-Phenyltetrazole-5-thiol-->(R)-5-chloro-2-(5-Methyl-1,4-diazepan-1-yl)benzo[d]oxazole-->2-Amino-4-chlorophenol-6-sulfonic acid-->3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2(3H)-benzoxazolone-->2,5-Dichlorobenzooxazole-->Acid Black 181-->Mordant Blue 13-->Chromate,bis[4-[[3-[(5-chloro-2-hydroxyphenyl)azo]-2,4-dihydroxyphenyl]azo]-3-hydroxy-7-nitro-1-naphthalenesulfonato]-,disodium hydrogen-->Mordant Black 56-->Mordant Blue 18-->Chromate(1-), [5-[[5-chloro-2-(hydroxy-κO)phenyl]azo-κN1]-4-hydroxy-6-(hydroxy-κO)-2-naphthalenesulfonato(3-)]hydroxy-, sodium-->Mordant Green 28-->Neutral Red 2gl-->Solvent Red 243-->Solvent Violet 58-->Mordant violet 40 (C.I. 14745)-->Acid Black 102

Chlorzoxazone 2-Amino-4-chloro-5-nitrophenol Betaine 2-Amino-4-chlorobenzoic acid Acetaminophen 2,4-Dichloro-6-nitrophenol Chloroacetic acid 2-Aminobenzylchloride CHLOROPHENOL ALTRENOGEST 5-CHLORO-2,4-DIMETHOXYPHENYL ISOCYANATE Glycine 4-Aminophenol 5-Chloro-2-methoxyaniline 2-Aminophenol Epichlorohydrin 3-Aminophenol 4-CHLORO-2-NITROPHENOL

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2-Amino-4-chlorophenol

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