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| | AROTINOLOL Basic information |
| Product Name: | AROTINOLOL | | Synonyms: | AROTINOLOL;Arottnolol;2-(3-tert-Butylamino-2-hydroxypropylthio)-4-(5-carbamoyl-2-thienyl)thiazole;2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-;2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-, (+-)-;NSC 317940;5-[2-[[3-(tert-butylamino)-2-hydroxy-propyl]thio]thiazol-4-yl]thiophene-2-carboxamide;5-[2-[3-(tert-butylamino)-2-hydroxy-propyl]sulfanyl-1,3-thiazol-4-yl]thiophene-2-carboxamide | | CAS: | 68377-92-4 | | MF: | C15H21N3O2S3 | | MW: | 371.54 | | EINECS: | | | Product Categories: | | | Mol File: | 68377-92-4.mol |  |
| | AROTINOLOL Chemical Properties |
| Melting point | 148-149° | | Boiling point | 599.8±60.0 °C(Predicted) | | density | 1.35 | | storage temp. | 2-8°C(protect from light) | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 13.71±0.20(Predicted) | | form | Solid | | color | Off-White to Pale Yellow |
| | AROTINOLOL Usage And Synthesis |
| Originator | Arotinolol,ZYF Pharm | | Uses | Arotinolol is both and alpha- and beta-adrenoceptor antagonist and is used to treat essential tremors and hypertension. | | Definition | ChEBI: Arotinolol is a member of thiophenes and an aromatic amide. | | Manufacturing Process | To a solution of 2-mercapto-4-(5'-carbamoyl-2'-thiophenyl)thiazole, 3.2 g in
20 ml of 0.3 % aqueous sodium hydroxide solution, 1-chloro-3-tbutylaminopropanol,
12.64 g in 20 ml of methanol was added, while the
temperature was maintained at 20°C.
The reaction solution was stirred at room temperature for 4 h, and then
condensed to a half volume in vacuo. The residual solution, added with 100 ml
of water, was extracted with chloroform. The chloroform extract was washed
with water, dried over anhydrous magnesium sulfate and evaporated in vacuo
to give 4.8 g of 2-(3'-t-butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'-
thiophenyl)thiazole, as crystals, melting point 234°-235.5°C (dec.,
recrystallized from methanol/water).
In practice it is usually used as hydrochloride. | | Therapeutic Function | Beta-adrenergic blocker |
| | AROTINOLOL Preparation Products And Raw materials |
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