|
| | GW0742 Chemical Properties |
| Melting point | 134.5-135.5 °C | | Boiling point | 591.5±60.0 °C(Predicted) | | density | 1.46±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: >5 mg/mL | | form | solid | | pka | 3.17±0.10(Predicted) | | color | white | | InChI | InChI=1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)29-9-19(27)28)30-10-18-12(2)26-20(31-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28) | | InChIKey | HWVNEWGKWRGSRK-UHFFFAOYSA-N | | SMILES | C(O)(=O)COC1=CC=C(SCC2SC(C3=CC=C(C(F)(F)F)C(F)=C3)=NC=2C)C=C1C |
| WGK Germany | 3 | | HS Code | 38220090 |
| | GW0742 Usage And Synthesis |
| Description | GW0742 is a PPARδ/β agonist very similar in molecular structure to GW501516 (Cardarine) — with the exception of one atom. It is often mentioned in comparison with Cardarine. This drug is mostly used by athletes to improve their stamina. The fat affecting properties of GW0742 also make it a good promoter of energy in the body. Additionally, this drug helps increase the oxidative abilities of your body muscles. | | Chemical Properties | Light Yellow Solid | | Uses | GW0742 is a small molecule agonist of the human Peroxisome Proliferator-Activated Recept δ (PPAR δ). It shows an EC50 of 1.1 nM against PPAR δ with 100-fold selectivity over the other human subtypes. | | Definition | ChEBI: GW 0742 is a monocarboxylic acid. | | Biological Activity | GW 0742 is a potent and highly selective PPARδ agonist. EC50 values are 0.001, 1.1 and 2 μM for transactivation of human PPARδ, -α, and -γ receptors respectively. Neuroprotective in rat cerebellar granule neuronal cultures after brief (12-hour) exposure but exhibits inherent toxicity after prolonged (48-hour) incubation. Increases rate of fatty acid oxidation and protects against ischemia/reperfusion injury in neonatal and adult cardiomyocytes. | | storage | Desiccate at +4°C |
| | GW0742 Preparation Products And Raw materials |
|
