GW0742

GW0742 Basic information
Product Name:GW0742
Synonyms:2-(4-(((2-(3-Fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylphenoxy);GW 0742X;GW 610742;GWdelta 0742;2-(4-(((2-(3-Fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylpheno;GW0742;[4-[[[2-[3-FLUORO-4-(TRIFLUOROMETHYL)PHENYL]-4-METHYL-5-THIAZOLYL]METHYL]THIO]-2-METHYLPHENOXY]ACETIC ACID;4-[2-(3-FLUORO-4-TRIFLUOROMETHYL-PHENYL)-4-METHYL-THIAZOL-5-YLMETHYLSULFANYL]-2-METHYL-PHENOXY-ACETIC ACID
CAS:317318-84-6
MF:C21H17F4NO3S2
MW:471.49
EINECS:1532714-185-1
Product Categories:Inhibitors;Intermediates & Fine Chemicals;All Inhibitors;Pharmaceuticals;Intracellular receptor;Inhibitor;317318-84-6
Mol File:317318-84-6.mol
GW0742 Structure
GW0742 Chemical Properties
Melting point 134.5-135.5 °C
Boiling point 591.5±60.0 °C(Predicted)
density 1.46±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: >5 mg/mL
form solid
pka3.17±0.10(Predicted)
color white
InChIInChI=1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)29-9-19(27)28)30-10-18-12(2)26-20(31-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28)
InChIKeyHWVNEWGKWRGSRK-UHFFFAOYSA-N
SMILESC(O)(=O)COC1=CC=C(SCC2SC(C3=CC=C(C(F)(F)F)C(F)=C3)=NC=2C)C=C1C
Safety Information
WGK Germany 3
HS Code 38220090
MSDS Information
ProviderLanguage
SigmaAldrich English
GW0742 Usage And Synthesis
DescriptionGW0742 is a PPARδ/β agonist very similar in molecular structure to GW501516 (Cardarine) — with the exception of one atom. It is often mentioned in comparison with Cardarine. This drug is mostly used by athletes to improve their stamina. The fat affecting properties of GW0742 also make it a good promoter of energy in the body. Additionally, this drug helps increase the oxidative abilities of your body muscles.
Chemical PropertiesLight Yellow Solid
UsesGW0742 is a small molecule agonist of the human Peroxisome Proliferator-Activated Recept δ (PPAR δ). It shows an EC50 of 1.1 nM against PPAR δ with 100-fold selectivity over the other human subtypes.
DefinitionChEBI: GW 0742 is a monocarboxylic acid.
Biological ActivityGW 0742 is a potent and highly selective PPARδ agonist. EC50 values are 0.001, 1.1 and 2 μM for transactivation of human PPARδ, -α, and -γ receptors respectively. Neuroprotective in rat cerebellar granule neuronal cultures after brief (12-hour) exposure but exhibits inherent toxicity after prolonged (48-hour) incubation. Increases rate of fatty acid oxidation and protects against ischemia/reperfusion injury in neonatal and adult cardiomyocytes.
storageDesiccate at +4°C
GW0742 Preparation Products And Raw materials
Raw materials(2-Bromo-4-methylthiazol-5-yl)methanol
4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide Erteberel (LY500307) T0070907 A 205804 Selumetinib WY-14643 GW-501516 GW0742 (2-METHYLPHENOXY)ACETIC ACID

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