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| | N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride Basic information |
| Product Name: | N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride | | Synonyms: | N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride;LORCAINIDE HYDROCHLORIDE;Isocainide hydrochloride;4'-Chloro-N-(1-isopropyl-4-piperidyl)-2-phenylacetanilide monohydrochloride;Benzeneacetamide, N-(4-chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl]-, monohydrochloride;Nsc310411;N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride USP/EP/BP;Lorcainide HCl | | CAS: | 58934-46-6 | | MF: | C22H28Cl2N2O | | MW: | 407.37652 | | EINECS: | 261-504-6 | | Product Categories: | | | Mol File: | 58934-46-6.mol |  |
| | N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride Chemical Properties |
| Melting point | 263° | | storage temp. | -20°C | | solubility | Soluble in DMSO (up to 20 mg/ml), in Water (up to 20 mg/ml), or in Ethanol (up to 20 mg/ml). | | form | White solid. | | color | Powder | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, distilled water or ethanol may be stored at -20°C for up to 1 month |
| | N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride Usage And Synthesis |
| Description | Lorcainide hydrochloride (58934-46-6) is a voltage-gated Na+?channel blocker.1?Protects murine cultured cortical neurons from injury induced by oxygen-glucose deprivation.2?Acts at the ouabain binding site of guinea pig cardiac Na+/K+?ATPase and inhibits the enzyme (IC50?= 34 μM).3 | | Uses | Cardiac depressant (anti-arrhythmic). | | References | 1) Sheldon?et al.?(1989),?Antiarrhythmic drugs and the cardiac sodium channel: current models; Clin. Chem.,?35?748
2) Lynch?et al.?(1995),?Sodium channel clockers reduce oxygen-glucose deprivation-induced cortical neuronal injury when combined with glutamate receptor antagonists; J. Pharmacol. Exp. Ther.,?273?554
3) Almotrefi?et al. (1999),?Class I antiarrhythmic drug effects on ouabain binding to guinea pig cardiac Na+ -K+ ATPase; Can. J. Physiol. Pharmacol.,?77?866 |
| | N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride Preparation Products And Raw materials |
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