Antazoline hydrochloride

Antazoline hydrochloride Basic information
Product Name:Antazoline hydrochloride
Synonyms:2-Phenyl-benzyl-amino-methylimidazolin hydrochloride;Phenazoline hydrochloride;LABOTEST-BB LT00134672;BENZYL-(4,5-DIHYDRO-1H-IMIDAZOL-2-YLMETHYL)-PHENYL-AMINE HCL;2-(N-PHENYL-N-BENZYL-AMINOMETHYL)-IMIDAZOLINE HCL;2-(N-BENZYLANILINOMETHYL)-2-IMIDAZOLINE HYDROCHLORIDE;2-(N-BENZYLANILINOMETHYL) IMIDAZOLINE HYDROCHLORIDE;ANTAZOLINE HCL
CAS:2508-72-7
MF:C17H20ClN3
MW:301.81
EINECS:219-719-8
Product Categories:Histamine receptor;2508-72-7
Mol File:2508-72-7.mol
Antazoline hydrochloride Structure
Antazoline hydrochloride Chemical Properties
Melting point 238 °C
storage temp. Inert atmosphere,Room Temperature
solubility DMSO (Slightly, Heated), Methanol (Slightly)
form neat
color White to Off-White
Merck 14,680
CAS DataBase Reference2508-72-7(CAS DataBase Reference)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 20/21/22-36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS NJ2150000
HS Code 2933.29.4300
MSDS Information
ProviderLanguage
SigmaAldrich English
Antazoline hydrochloride Usage And Synthesis
Chemical PropertiesWhite or almost white crystalline powder
OriginatorAntistine HCl,Ciba,US,1948
UsesAntihistaminic;H1 antagonist
UsesAntazoline Hydrochloride acts as a histamine H1 receptor blocker, functioning as an antihistamine pharmaceutical.
UsesImidazoline binding site ligand and an antihistamine
Manufacturing Process15.4 parts of 2-chloromethylimidazoline hydrochloride, 45.8 parts of Nbenzylaniline and 150 parts of alcohol are heated in an oil bath at 100° to 110°C. After distilling off the alcohol, the reaction mass is maintained at this temperature for a further 3 hours and then triturated with water and 10 parts of sodium bicarbonate. The unconsumed benzylaniline is extracted with ether and the aqueous solution neutralized with dilute hydrochloric acid. By evaporating this solution and extracting the residue with alcohol there is obtained 2-(N-phenyl-N-benzylaminomethyl)imidazoline hydrochloride in the form of colorless crystals of melting point 227° to 229°C.
Therapeutic FunctionAntihistaminic
Biological ActivityImidazoline binding site ligand; a potent inducer of insulin secretion in rat pancreas. Also an antihistamine.
Antazoline hydrochloride Preparation Products And Raw materials
Raw materialsN-Phenylbenzylamine-->Hydrochloric acid-->2-(CHLOROMETHYL)-4,5-DIHYDRO-1H-IMIDAZOLE MONOHYDROCHLORIDE
Nifedipine Antazoline Sulfate Antazoline hydrochloride C-(1H-IMIDAZOL-2-YL)-METHYLAMINE 2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride Naphazoline hydrochloride Amprolium Hydrochloride Xylometazoline hydrochloride Topotecan hydrochloride AURORA KA-401 Methylamine Trimethylamine Meglumine Methylamine hydrochloride ANTAZOLINE METHANESULFONATE Antazoline Trimethylamine hydrochloride ANTAZOLINE PHOSPHATE Antazoline Hcl

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