Propranolol was responsible for sensitisation of workers
in drug synthesis. In one case, epichlorhydrin was
used for the production of both propranolol and
oxprenolol.
Chemical Properties
Colorless crystals.Soluble in
water and alcohol; insoluble in benzene and ether.
ChEBI: A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
Brand name
Inderal (Wyeth); Innopran (Reliant).
Hazard
Highly toxic.
Contact allergens
Propranolol is a beta-blocking agent that was responsible
for the sensitization of workers in drug synthesis.
In one case, epichlorhydrin was used for the production
of drugs propranolol and oxprenolol. Crossreactivity
is expected between beta-blockers.
