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| | Methyl chloroacetate Basic information |
| | Methyl chloroacetate Chemical Properties |
| Melting point | -33 °C | | Boiling point | 130 °C740 mm Hg(lit.) | | density | 1.238 g/mL at 25 °C(lit.) | | vapor density | 3.8 (vs air) | | vapor pressure | 10 mm Hg ( 25 °C) | | refractive index | n20/D 1.422(lit.) | | Fp | 125 °F | | storage temp. | Store at <= 20°C. | | solubility | 51.6g/l (slow decomposition) | | form | Liquid | | color | Clear colorless | | PH | 4.6 (28g/l, H2O, 20℃) | | explosive limit | 4.6-18.5%(V) | | Water Solubility | 28 g/L (20 ºC) | | Merck | 14,6042 | | BRN | 506255 | | LogP | 0.63 at 20℃ | | CAS DataBase Reference | 96-34-4(CAS DataBase Reference) | | NIST Chemistry Reference | Acetic acid, chloro-, methyl ester(96-34-4) | | EPA Substance Registry System | Acetic acid, 2-chloro-, methyl ester (96-34-4) |
| | Methyl chloroacetate Usage And Synthesis |
| Chemical Properties | clear colorless liquid with a slight irritating odor. It is miscible with organic solvents such as ethanol, ether, acetone and benzene. Slightly soluble in water. | | Uses | Methyl chloroacetate is used as a solvent and chemical intermediate. It acts as a precursor in the preparation of (carboxymethyl) trimethylammonium chloride esters. Further, it is used in the preparation of octakis-(carbethoxymethoxy)calix[8]arene. It is employed as an extraction solvent during the separation of neutral compounds. In addition to this, it is used in the synthesis of dimethyl carbonate. | | Application | Methyl chloroacetate (MC) is a halogenated ester mainly used as a solvent in organic synthesis or in the preparation of several compounds. Typically, MC is used in the preparation of (carboxymethyl) trimethylammonium chloride estersor in the synthesis of octakis- (carbethoxymethoxy)calix[8]arene. Additionally, methyl chloroacetate acts as an extraction solvent during the separation of neutral compounds with concentration enhancement using coupling liquid–liquid semi-microextraction with micellar electrokinetic chromatography through oncapillary decomposition. | | Preparation | Methyl chloroacetate is prepared by esterification of chloroacetic acid with methanol.
Reaction: Methanol and chloroacetic acid are uniformly mixed in a weight ratio of 0.366:1, heated with stirring, and the esterification reaction is carried out at 105-110 °C. In the reaction process, the ternary azeotrope of methyl chloroacetate, water and methanol is continuously steamed, layered through the ester separator, the separated methanol and water are returned to the reaction pot, and the separated crude ester is made of sodium carbonate. neutralize. The neutralized crude ester is firstly cut out the 130°C fraction by atmospheric distillation, and then subjected to vacuum distillation to collect the 65°C (8kPa) fraction, which is the finished product of methyl chloroacetate. The yield is about 96%. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 50, p. 3408, 1985 DOI: 10.1021/jo00218a034 | | General Description | A crystalline solid or a solid dissolved in a liquid. Insoluble in water and denser than water. Contact may slightly irritate skin, eyes and mucous membranes. May be slightly toxic by ingestion. Used to make other chemicals. | | Air & Water Reactions | Highly flammable. Insoluble in water. | | Reactivity Profile | Methyl chloroacetate is a halogenated ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. | | Hazard | Toxic by ingestion and inhalation. | | Health Hazard | Extremely corrosive to the eyes, skin, nose, throat, and upper respiratory tract. Inhalation may be fatal as a result of spasm, inflammation and edema of the larynx and bronchi, chemical pneumonitis, and pulmonary edema. Symptoms of exposure include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting. | | Fire Hazard | Special Hazards of Combustion Products: Toxic fumes of hydrogen chloride | | Safety Profile | Poison by ingestion.
Moderately toxic by inhalation and
subcutaneous routes. Flammable when
exposed to heat or flame; can react
vigorously with oxidizing materials. When
heated to decomposition it emits toxic
fumes of Cl-. | | Purification Methods | Shake the ester with saturated aqueous Na2CO3 (three times), aqueous 50% CaCl2 (three times), saturated aqueous NaCl (twice), dry (Na2SO4) and fractionally distil it. Very toxic. [Beilstein 2 IV 480.] |
| | Methyl chloroacetate Preparation Products And Raw materials |
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