ChemicalBook Product Catalog Biochemical Engineering Nucleoside drugs Nucleotides and their analogs 5'-O-Dimethoxytrityl-deoxythymidine

5'-O-Dimethoxytrityl-deoxythymidine

5'-O-Dimethoxytrityl-deoxythymidine Basic information
Product Name:5'-O-Dimethoxytrityl-deoxythymidine
Synonyms:5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYTHYMIDINE;5'-O-[Bis(4-methoxyphenyl)benzyl]-2'-deoxythymidine;5'-O-(4,4'-DIMETHOXYTRITYL)THYMIDINE;5-O-(4,4-DIMETHOXYTRITYL)THYMIDINE;5'-O-DIMETHOXYTRITYL-DEOXYTHYMIDINE;5'-O-(DIMETHOXYTRITYL)-THYMIDINE;5'-O-DMT-THYMIDINE;5'-O-(p,p'-dimethoxytrityl)thymidine
CAS:40615-39-2
MF:C31H32N2O7
MW:544.59
EINECS:255-003-1
Product Categories:Biochemistry;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents;Bases & Related Reagents;Carbohydrates & Derivatives;Nucleotides;PNS
Mol File:40615-39-2.mol
5'-O-Dimethoxytrityl-deoxythymidine Structure
5'-O-Dimethoxytrityl-deoxythymidine Chemical Properties
Melting point 114-116 °C (subl.)(lit.)
Boiling point 618.41°C (rough estimate)
density 1.2483 (rough estimate)
vapor pressure 0Pa at 20℃
refractive index 7 ° (C=1, MeOH)
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
pka9.55±0.10(Predicted)
form Powder
color White to off-white
Water Solubility 3mg/L at 20℃
BRN 599297
Stability:Store in Freezer
LogP4.61 at 20℃
CAS DataBase Reference40615-39-2(CAS DataBase Reference)
EPA Substance Registry SystemThymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]- (40615-39-2)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
F 1-3-10
Hazard Note Irritant
HS Code 29349990
MSDS Information
ProviderLanguage
5'-O-[Bis(4-methoxyphenyl)benzyl]-2'-deoxythymidine English
SigmaAldrich English
ACROS English
ALFA English
5'-O-Dimethoxytrityl-deoxythymidine Usage And Synthesis
Chemical PropertiesWhite Powder
Uses5'-O-(4,4'-Dimethoxytrityl)thymidine is used in the solid-phase synthesis of polynucleotides and polythymidylic acids by the block coupling phosphotriester method. Further, it is used in the stereoselective synthesis of 3'-deoxy-3'-threo-hydroxymethyl nucleoside. In addition to this, it is used as a research tool for antiviral and anticancer studies.
General Description5′-O-(4,4′-Dimethoxytrityl)thymidine is a pyrimidine.
Flammability and ExplosibilityNotclassified
5'-O-Dimethoxytrityl-deoxythymidine Preparation Products And Raw materials
Preparation Products5'-O-(4,4'-DIMETHOXYTRITYL)-N4-BENZOYL-5-METHYL-2'-DEOXYCYTIDINE-->Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[P-methyl-N,N-bis(1-methylethyl)phosphonamidite], (S)- (9CI)-->5'-Dimethoxytrityl-3'-deoxythymidine 2'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
5'-O-(DIMETHOXYTRITYL)-5-(1-PROPYNYL)-2'-O-METHYLURIDINE 5'DIMETHOXYTRITYL DA(BZ)+DG(IBU)+DC(BZ)+T BETA-CYANOETHYL PHOSPHORAMIDITE 5-[N-(2-AMINOETHYL)-3-(E)-ACRYLAMIDO]-5'-O-(DIMETHOXYTRITYL)-2'-DEOXYURIDINE [E]-5-(2-CARBOMETHOXYVINYL)-5'-O-(DIMETHOXYTRITYL)-2'-DEOXYURIDINE 5'-O-(DIMETHOXYTRITYL)-2'-O-METHYL-5-METHYLURIDINE 5'-O-(4,4'-DIMETHOXYTRITYL) [5'-3H]- THYMIDINE 5'-O-(4,4'-DIMETHOXYTRITYL) [METHYL-3H]- THYMIDINE 5'-O-(DIMETHOXYTRITYL)-5-(1-PROPYNYL)-2'-DEOXYURIDINE 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYTHYMIDINE-3'-(METHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE m-Anisyl alcohol 5-[N-(6-AMINOHEXYL)-3-(E)-ACRYLAMIDO]-5'-O-(DIMETHOXYTRITYL)-2'-DEOXYURIDINE 5'DIMETHOXYTRITYL DC(BZ)+T BETA-CYANOETHYL PHOSPHORAMIDITE 5'-O-(DIMETHOXYTRITYL)-5-[N-(2-(TRIFLUOROACETAMIDO)ETHYL)-3-(E)-ACRYLAMIDO]-2'-DEOXYURIDINE 5'-O-(4,4'-DIMETHOXYTRITYL) [4,6-14C]- THYMIDINE 5'DIMETHOXYTRITYL T BETA-CYANOETHYL PHOSPHORAMIDITE 5'-O-(4,4'-Dimethoxytrityl)-thymidine-3'-O-succinic acid 5'-Dimethoxytrityl-3'-deoxythymidine 2'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite 5'-O-Dimethoxytrityl-deoxythymidine
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