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| | OLEYLOXYETHYL PHOSPHORYLCHOLINE Basic information |
| Product Name: | OLEYLOXYETHYL PHOSPHORYLCHOLINE | | Synonyms: | 1-O-9Z-OCTADECENYLETHYLENEGLYCOL-2-O-PHOSPHORYLCHOLINE;PHOSPHORYLCHOLINE, OLEOYLOXYETHYL ESTER;OLEYLOXYETHYLPHOSPHOCHOLINE;OLEYLOXYETHYL PHOSPHORYLCHOLINE;OLEYOXYETHYL PHOSPHORYLCHOLINE;(17Z)-4-Hydroxy-N,N,N-trimethyl-3,5,8-trioxa-4-phosphahexacos-17-en-1-aminium inner salt 4-oxide;NPLMVGGTFDUQHL-SEYXRHQNSA-N;OLEYLOXYETHYL PHOSPHORYLCHOLINE USP/EP/BP | | CAS: | 84601-19-4 | | MF: | C25H52NO5P | | MW: | 477.67 | | EINECS: | | | Product Categories: | | | Mol File: | 84601-19-4.mol |  |
| | OLEYLOXYETHYL PHOSPHORYLCHOLINE Chemical Properties |
| storage temp. | -20°C | | solubility | ≤16mg/ml in DMSO;16mg/ml in dimethyl formamide | | form | solution in ethanol. |
| | OLEYLOXYETHYL PHOSPHORYLCHOLINE Usage And Synthesis |
| Description | Oleyloxyethyl phosphorylcholine is an inhibitor of PLA2 with an IC50 value of 6.2 μM for porcine pancreatic PLA2. | | in vitro | to examine the phospholipids including oleyloxyethyl phosphorylcholine as pla2 inhibitors, the enzyme assay was employed. determinations were performed below critical micelle concentration. porcine pancreatic pla2 and phospholipid inhibitor were preincubated for 2 min at 37°c in buffer at ph 8.5. introduction of [l4c]arachidonate phosphatidylcholine initiated the enzymatic reaction, which is quenched after 5 min at 37°c. in this manner 50% inhibitor concentrations were determined for mepacrine and alkylphosphorylcholines, indicating oleyloxyethyl phosphorylcholine was an inhibitor of pla2 with an ic50 of 6.2 μm for porcine pancreatic pla2 [1]. | | IC 50 | 6.2 μm for porcine pancreatic pla2 | | references | [1] magolda, r. l.,ripka, w.c.,galbraith, w., et al. novel synthesis of potent site-specific phospholipase a2 inhibitors. book: prostaglandins, leukotrienes and lipoxins 669-676 (1985). |
| | OLEYLOXYETHYL PHOSPHORYLCHOLINE Preparation Products And Raw materials |
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