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| Product Name: | NH125 | | Synonyms: | eEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem;EEF-2 KINASE INHIBITOR;1-Hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazoliumiodide;eEF-2 Kinase Inhibitor, NH125;NH125 USP/EP/BP;3-Benzyl-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide;NH 125,Calmodulin-dependent protein kinases,NH-125,Calmodulin-dependent kinases,NH125,Inhibitor,Autophagy,inhibit,Fungal,Virus Protease,Bacterial,CaMK | | CAS: | 278603-08-0 | | MF: | C27H45N2.I | | MW: | 524.567 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 278603-08-0.mol |  |
| | NH125 Chemical Properties |
| Melting point | 88.2-94.9 °C | | storage temp. | -20°C | | solubility | DMSO: 20 mg/mL | | form | solid | | color | white to off-white |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| | NH125 Usage And Synthesis |
| Uses | NH125 is an inhibitor of multiple kinases. It kills methicillin-resistant Staphylococcus. | | Biological Activity | Histidine protein kinase and eukaryotic elongation factor 2 (eEF-2) kinase (CaMK III) inhibitor (IC 50 = 60 nM) that displays 125-fold, > 1300-fold and > 1500-fold selectivity over PKC, PKA and CaMK II respectively. Exhibits anticancer activity in a variety of malignant cell lines (IC 50 values are 0.7 - 4.8 μ M) and blocks G 1 /S cell cycle progression. Also is an effective antibacterial agent in vitro (IC 50 = 6.6 μ M) and in vivo . | | Biochem/physiol Actions | NH125 exhibits anti-proliferation activity against many cancer cells. It also exhibits antibacterial effects by inhibiting bacterial histidine protein kinase. | | storage | Desiccate at -20°C | | references | [1]. arora, s., et al., identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines. cancer res, 2003. 63(20): p. 6894-9.
[2]. cheng, y., et al., integrated regulation of autophagy and apoptosis by eef2k controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells. autophagy, 2013. 9(2): p. 208-19.
[3]. usui, t., et al., eukaryotic elongation factor 2 kinase regulates the development of hypertension through oxidative stress-dependent vascular inflammation. am j physiol heart circ physiol, 2013. 305(5): p. h756-68. |
| | NH125 Preparation Products And Raw materials |
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