AMITRIPTYLINE METABOLITE (+/-)-

AMITRIPTYLINE METABOLITE (+/-)- Basic information

Product Name:	AMITRIPTYLINE METABOLITE (+/-)-
Synonyms:	AMITRIPTYLINE METABOLITE (+/-)-;AMITRIPTYLINE METABOLITE (+-)-(E)-10-HYD ROXYLA;(11E)-11-[3-(dimethylamino)propylidene]-5,6-dihydrodibenzo[2,1-b:2',1'-f][7]annulen-5-ol;5H-Dibenzo[a,d]cyclohepten-10-ol, 5-[3-(dimethylamino)propylidene]-10,11-dihydro-, (5E)-;10-Hydroxy (E)-Amitriptyline;Amitriptyline metabolite, (±)-E-10-hydroxylated-;(E)-5-(3-(Dimethylamino)propylidene)-10,11-dihydro-5H-dibenzo[a,d][7]annulen-10-ol
CAS:	64520-05-4
MF:	C20H23NO
MW:	293.4
EINECS:
Product Categories:
Mol File:	64520-05-4.mol

AMITRIPTYLINE METABOLITE (+/-)- Chemical Properties

Melting point	97-99 °C
Boiling point	453.3±45.0 °C(Predicted)
density	1.151±0.06 g/cm3(Predicted)
storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility	0.1 M HCl: soluble
pka	13.89±0.20(Predicted)
form	solid
color	white
Stability:	Hygroscopic
EPA Substance Registry System	5H-Dibenzo[a,d]cyclohepten-10-ol, 5-[3-(dimethylamino)propylidene]-10,11-dihydro-, (5E)- (64520-05-4)

Safety Information

Safety Statements	22-24/25
WGK Germany	3

MSDS Information

AMITRIPTYLINE METABOLITE (+/-)- Usage And Synthesis

Uses	(5E)-5-[3-(dimethylamino)propylidene]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol is a metabolite of amitriptyline (A633350) which is a dibenzocycloheptadiene derivative and an antidepressant (1). Amitriptyline is also a TrkA and TrkB receptor agonist and exhibits neurotrophic and anti-inflammatory activities (2,3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA).
Definition	ChEBI: E-10-Hydroxyamitriptyline is an organic tricyclic compound.
Biochem/physiol Actions	Metabolite of amitriptyline, tricyclic antidepressant; chromatographic standard.

AMITRIPTYLINE METABOLITE (+/-)- Preparation Products And Raw materials

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