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SORAFENIB N-OXIDE

SORAFENIB N-OXIDE Basic information
Product Name:SORAFENIB N-OXIDE
Synonyms:Sorafenib impurity 23/Sorafenib N-Oxide/4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-2-(methylcarbamoyl)pyridine 1-oxide;SORAFENIB N-OXIDE;4-[4-[[[[4-Chloro-3-(trifluoroMethyl)phenyl]aMino]carbonyl]aMino]phenoxy]-N-Methyl-2-pyridinecarboxaMide 1-Oxide;Sorafenib Impurity 27(Sorafenib N-Oxide);2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-, 1-oxide;4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-2-(methylcarbamoyl)pyridine 1-oxide;Sorafenib impurities172;Sorafenib impurities11
CAS:583840-03-3
MF:C21H16ClF3N4O4
MW:480.82
EINECS:
Product Categories:Metabolites;Various Metabolites and Impurities
Mol File:583840-03-3.mol
SORAFENIB N-OXIDE Structure
SORAFENIB N-OXIDE Chemical Properties
Melting point 220-222oC
Boiling point 591.7±50.0 °C(Predicted)
density 1.45±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility DMSO: soluble; Methanol: very slightly soluble, heated
form A solid
pka12.89±0.70(Predicted)
Safety Information
MSDS Information
SORAFENIB N-OXIDE Usage And Synthesis
Chemical PropertiesPale Yellow Solid
UsesA metabolite of Sorafenib, a potent Raf kinase inhibitor.
SORAFENIB N-OXIDE Preparation Products And Raw materials
Sorafenib related compound 10 2-Chloro-5-nitrobenzotrifluoride 2-Chlorobenzotrifluoride 2-chloro-1-nitro-3-(trifluoromethyl)benzene 4-(4-Aminophenoxy)-N-methylpicolinamide 1,4-Benzoquinoneimine 1-(4-chloro-3-(trifluoromethyl)phenyl)urea 4-HYDROXYPHENYLFORMAMIDE Sorafenib Impurity 35 Sorafenib 2-Pyridinecarboxylic acid, 4-(4-aMinophenoxy)- Sorafenib Impurity 43 4-METHOXYPYRIDINE-N-OXIDE HYDRATE, 99 4-(4-AMINOPHENOXY)PYRIDINE 4-PHENOXYPYRIDINE-N-OXIDE 4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID AMIDE 2-METHYL-4-METHOXYPYRIDINE-N-OXIDE SORAFENIB N-OXIDE
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