ChemicalBook Product Catalog Organic Chemistry Carboxylic acids and derivatives Cereblon Ligand 1

Cereblon Ligand 1

Cereblon Ligand 1 Basic information
Product Name:Cereblon Ligand 1
Synonyms:Cereblon Ligand 1;2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetic acid;Cereblon ligand 3;Pomalidomide Related Compound 1;Thalidomide-Acid;Acetic acid, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-;2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetic acid;Thalidomide-4-hydroxyacetate
CAS:1061605-21-7
MF:C15H12N2O7
MW:332.27
EINECS:
Product Categories:
Mol File:1061605-21-7.mol
Cereblon Ligand 1 Structure
Cereblon Ligand 1 Chemical Properties
Boiling point 660.5±55.0 °C(Predicted)
density 1.606±0.06 g/cm3(Predicted)
solubility Soluble in DCM
form A crystalline solid
pka2.95±0.10(Predicted)
Safety Information
HS Code 2933998090
MSDS Information
Cereblon Ligand 1 Usage And Synthesis
DescriptionThalidomide-Acid is a linker of Thalidomide which is commonly used as a precursor to PROTAC that hijacks cereblon as the E3 ubiquitin ligase component.
UsesThalidomide-4-hydroxyacetate is a proteolysis targeting chimeras which allows for the optical control of protein degradation.
storageStore at RT
Cereblon Ligand 1 Preparation Products And Raw materials
E3 Ligase Ligand-Linker Conjugates 20 Thalidomide-linker 13 L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)- tert-butyl 3,3'-(2-aMino-2-((3-tert-butoxy-3-oxopropoxy)Methyl)propane-1,3-diyl)bis(oxy)dipropanoate Thalidomide-O-PEG4-Boc 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione Thalidomide-O-amido-C8-NH2 hydrochloride Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride Thalidomide-O-amido-C4-NH2 hydrochloride Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl- Thalidomide-linker 10 Thalidomide-O-PEG4-Propargyl E3 Ligase Ligand-Linker Conjugates 19 Protein degrader 1 (TFA) 4-Hydroxy ThalidoMide E3 Ligase Ligand-Linker Conjugates 21 1H-Isoindole-1,3(2H)-dione, 4-[2-(2-aminoethoxy)ethoxy]-2-(2,6-dioxo-3-piperidinyl)-
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