N-alpha-(tert-Butoxycarbonyl)-L-lysine

N-alpha-(tert-Butoxycarbonyl)-L-lysine Basic information
Product Name:N-alpha-(tert-Butoxycarbonyl)-L-lysine
Synonyms:N2-Boc-L-lysine;N-alpha-Acetyl-Nε;n-Boc-L-lysine;Boc-Lys-OH >=99.0% (NT);Boc-Lys-OH 99%;(2S)-6-amino-2-(tert-butoxycarbonylamino)hexanoic acid;(2S)-6-amino-2-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid;(S)-2-[(tert-Butyloxycarbonyl)amino]-6-aminohexanoic acid
CAS:13734-28-6
MF:C11H22N2O4
MW:246.3
EINECS:237-303-4
Product Categories:Lysine [Lys, K];Boc-Amino Acids and Derivative;Amino Acids (N-Protected);Biochemistry;Boc-Amino Acids;Boc-Amino acid series;Amino Acids
Mol File:13734-28-6.mol
N-alpha-(tert-Butoxycarbonyl)-L-lysine Structure
N-alpha-(tert-Butoxycarbonyl)-L-lysine Chemical Properties
Melting point ~205 °C (dec.)(lit.)
alpha 22 º (c=2, CH3OH)
Boiling point 389.3°C (rough estimate)
density 1.1313 (rough estimate)
refractive index 21.5 ° (C=2, MeOH)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Acetic Acid (Slightly), Methanol (Slightly, Sonicated), Water (Slightly, Heated,
pka3.92±0.21(Predicted)
form Powder
color White
optical activity[α]20/D +4.6±0.5°, c = 2% in H2O
Water Solubility Soluble in water. Slightly soluble in methanol.
BRN 4252546
CAS DataBase Reference13734-28-6(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22-36/37/38
Safety Statements 24/25-36-26
WGK Germany 3
HS Code 2924 19 00
HazardClass IRRITANT
MSDS Information
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N-alpha-(tert-Butoxycarbonyl)-L-lysine English
SigmaAldrich English
ACROS English
N-alpha-(tert-Butoxycarbonyl)-L-lysine Usage And Synthesis
Chemical Propertieswhite to off-white powder
UsesN-Boc-L-lysine is a protected analogue of a major amino acid participating in the binding of AcH to proteins. N-Boc-L-lysine as well as other t-butoxycarbonyl (Boc) amino acids can be converted to the ir respective amino acids via cleavage of the urethane bond.
UsesN-Boc-L-lysine is a protected analogue of a major amino acid participating in the binding of AcH to proteins. N-Boc-L-lysine as well as other t-butoxycarbonyl (Boc) amino acids can be converted to their respective amino acids via cleavage of the urethane bond.
UsesBoc-Lys-OH (Nα-Boc-L-lysine) can be used as a building block to synthesize:
  • A heterotrifunctional peptide-based linker molecule applicable as a bio-labeling reagent.
  • Lysine derivatives of azamacrocycle and anthraquinone.
  • Boc-Lys(Bn4-DTPA)-OH, a precursor to synthesize diethylene triamine pentaacetic acid (DTPA) containing peptides.
  • A ferrocene-amino acid conjugate which is used in developing chemical warfare agent (CWA) sensor.

N-alpha-(tert-Butoxycarbonyl)-L-lysine Preparation Products And Raw materials
Preparation ProductsN-Boc-N'-Fmoc-L-Lysine-->(2S)-2-amino-6-{[(2-azidoethoxy)carbonyl]amino}hexanoic acid-->(S)-(2-OXO-AZEPAN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER-->N6-{[(2-Phenylethyl)amino]carbonothioyl}lysine (PEITC-Lys)-->N-α-Boc-propargyl-lysine-OH-->H-Lys(ivdde)-OH
BOC-LYS(BOC)-ONP N-Boc-N'-(2-chlorobenzyloxycarbonyl)-L-lysine BOC-LYS(FOR)-OH N-Boc-N'-Cbz-L-lysine BOC-LYS(BOC)-OH DCHA BOC-LYS(TOS)-OH BOC-LYS(TFA)-OSU N,N'-Di-Boc-L-lysine hydroxysuccinimide ester BOC-LYS(Z)-OH DCHA BOC-LYS(AC)-OH HCL BOC-LYS(ME)2-OH BOC-LYS(Z)-OSU BOC-L-LYSINE (CI-Z) BOC-LYS(TFA)-OH BOC-LYS(2-BROMO-Z)-OH BOC-LYS(Z)-ONP N-alpha-(tert-Butoxycarbonyl)-L-lysine N-Boc-N'-Fmoc-L-Lysine

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