ChemicalBook Product Catalog Chemical Reagents Organic reagents Aromatics N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide

N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide

N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide Basic information
Product Name:N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide
Synonyms:N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]METHACRYLAMIDE EPOXIDE (INTERMEDIATE OF BICALUTAMIDE);4’-Cyano-3’-trifluoromethyl-2,3-epoxy-2-methylpropioanilide;N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-2-Methyloxiranecarboxamide ( For Bicalutamide );N-[4-Cyano-3-(trifluoroMethyl)phenyl]MethacrylaMid;N-[4-Cyano-3-(triflu;n-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide;N-4-CYANO-3-(TRIFLUOROMETHYL)PHENYLMETHACRYLAMIDE EPOXIDE;1,2-EPOXY-2-METHYL-N-[4-CYANO-3-(TRIFLUOROMETHYL)]
CAS:90357-51-0
MF:C12H9F3N2O2
MW:270.21
EINECS:618-536-4
Product Categories:Bicalutamide;API intermediates;Chemical intermediate for Bicalutamide
Mol File:90357-51-0.mol
N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide Structure
N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide Chemical Properties
Melting point 151-152 °C
Boiling point 436.4±45.0 °C(Predicted)
density 1.42±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
pka12.08±0.70(Predicted)
form Solid
color White to Off-White
CAS DataBase Reference90357-51-0(CAS DataBase Reference)
Safety Information
Safety Statements 24/25
HS Code 29269090
MSDS Information
N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide Usage And Synthesis
UsesN-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methyl-2-oxiranecarboxamide, is an intermediate in synthesis of more complex pharmaceutical compounds. It is used in the synthesis of potential impurities of Bicalutamide (B382000), which is an oral nonsteroidal, anti-androgen drug used for prostate cancer.
Desfluoro Bicalutamide Bicalutamide 4-Amino-2-(trifluoromethyl)benzonitrile Oxiranecarboxamide, N-phenyl- (9CI) 4-amino-2-methylbenzonitrile Acrylamide 2-(Trifluoromethyl)benzonitrile Trifluoromethyl (R)-Bicalutamide PHENYL VALERATE N,N'-Methylenebisacrylamide 2,2-Dibromo-2-cyanoacetamide 4-ACETAMIDO-2-METHYLBENZONITRILE Cyano 4-CYANO-3-(TRIFLUOROMETHYL)ACETANILIDE Phenylhydrazine Methacrylamide N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide
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