ChemicalBook Product Catalog Biochemical Engineering Inhibitors Siremadlin

Siremadlin

Siremadlin Basic information
Product Name:Siremadlin
Synonyms:(6S)-5-(5-chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)-Pyrrolo[3,4-d]imidazol-4(1H)-one;HDM-201;NVP-HDM201;CS-2613;CS-2787;HDM201; HDM 201; HDM-201; NVP-HDM201; NVP-HDM-201; NVP-HDM 201;(S)-5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one;Siremadlin
CAS:1448867-41-1
MF:C26H24Cl2N6O4
MW:555.41
EINECS:
Product Categories:
Mol File:1448867-41-1.mol
Siremadlin Structure
Siremadlin Chemical Properties
Boiling point 736.5±70.0 °C(Predicted)
density 1.47±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : ≥ 56.75 mg/mL (102.18 mM)
pka1.33±0.29(Predicted)
Safety Information
MSDS Information
Siremadlin Usage And Synthesis
UsesSiremadlin is an oral biologic agent that is a selective inhibitor of the p53-MDM2 interaction and is being investigated for the treatment of patients with myeloid malignancies after showing single agent activity in preclinical studies. the safety profile of Siremadlin did not differ significantly between tumor types and treatment regimens.
Siremadlin Preparation Products And Raw materials
NVP-BEZ 235 NVP-TAE684 NVP-LCQ195 TAE226 (NVP-TAE226) N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide NVP-BGT226 NVP-BSK805 6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitriledihydrochloride NVP-BAW2881
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