ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyridine compound Pyridine derivatives PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE

PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE

PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE Basic information
Product Name:PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE
Synonyms:2-Isoniazid Impurity;AKOS B014996;AKOS BBS-00004147;2-PICOLINYL HYDRAZIDE;ART-CHEM-BB B014996;PYRIDINE-2-CARBOHYDRAZIDE;PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE;2-pyridinecarboxylic acid hydrazide
CAS:1452-63-7
MF:C6H7N3O
MW:137.14
EINECS:
Product Categories:Amines, Aromatics, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Amines;Aromatics;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;AMIDE
Mol File:1452-63-7.mol
PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE Structure
PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE Chemical Properties
Melting point 100°C
density 1.244
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka11.29±0.10(Predicted)
color White to Off-White
CAS DataBase Reference1452-63-7(CAS DataBase Reference)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-22
Safety Statements 26-36/37/39-24/25
HazardClass IRRITANT
HS Code 29333990
MSDS Information
PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE Usage And Synthesis
Chemical PropertiesWhite to off-white solid
UsesPyridine-2-carboxylic acid hydrazide is an impurity of Isoniazid (I821450), which is an antibiotic for treatment of Mycobacterium tuberculosis and inhibits mycolic acid biosynthesis. Intermediate used for the synthesis of analogs of antitumor agent 1-acetyl-2-picolinoylhydrazine.
PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE Preparation Products And Raw materials
Raw materialsEthyl acetate-->Methanol-->Dichloromethane-->Thionyl chloride-->Hydrazinium hydroxide solution-->2-Picolinic acid
Preparation Products3-(2-PYRIDYL)-5,6-DIPHENYL-1,2,4-TRIAZINE
N'-(5-bromo-2-hydroxybenzylidene)-2-pyridinecarbohydrazide 2-(2-methoxyphenoxy)-N'-(2-pyridinylcarbonyl)acetohydrazide SALOR-INT L139440-1EA SALOR-INT L137936-1EA Pyridine-2,6-dicarbohydrazide SALOR-INT L478555-1EA 4-AMINO-3,5,6-TRICHLOROPYRIDINE-2-CARBOHYDRAZIDE SALOR-INT L478563-1EA 4-CHLOROPYRIDINE-2,6-DICARBOHYDRAZIDE N'2-(2-CHLOROACETYL)-3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOHYDRAZIDE N-[1-AZA-2-[2-[(4,6-DIMETHOXYPYRIMIDIN-2-YL)OXY]PHENYL]ETHENYL]PYRIDINE-2-CARBOXAMIDE 2-(3-methoxyphenoxy)-N'-(2-pyridinylcarbonyl)acetohydrazide SALOR-INT L136417-1EA 2-phenoxy-N'-(2-pyridinylcarbonyl)propanohydrazide SALOR-INT L478261-1EA 1-Acetyl-2-picolinoylhydrazine 4-CHLORO-PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE
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