DIETHYL BROMOMALONATE

DIETHYL BROMOMALONATE Basic information

Product Name:	DIETHYL BROMOMALONATE
Synonyms:	alpha-Bromomalonic ester;bromo-propanedioicacidiethylester;Diethyl alpha-bromomalonate;Malonic acid, bromo-, diethyl ester;ETHYL BROMOMALONATE;DIETHYL BROMOMALONATE;BROMO DIETHYL MALONATE;BROMOMALONIC ACID DIETHYL ESTER
CAS:	685-87-0
MF:	C7H11BrO4
MW:	239.06
EINECS:	211-683-1
Product Categories:	Building Blocks;C6 to C7;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;C6 to C7;Carbonyl Compounds;Esters;bc0001
Mol File:	685-87-0.mol

DIETHYL BROMOMALONATE Chemical Properties

Melting point	-54°C
Boiling point	233-235 °C (lit.)
density	1.402 g/mL at 25 °C (lit.)
refractive index	n20/D 1.451(lit.)
Fp	>230 °F
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform, Hexanes
form	Liquid
pka	9.29±0.46(Predicted)
Specific Gravity	1.402
color	Clear colorless to slightly yellow
Water Solubility	Does not mix well with water.
Sensitive	Lachrymatory
BRN	509768
CAS DataBase Reference	685-87-0(CAS DataBase Reference)
EPA Substance Registry System	Propanedioic acid, 2-bromo-, 1,3-diethyl ester (685-87-0)

Safety Information

Hazard Codes	C
Risk Statements	34
Safety Statements	26-36/37/39-45
RIDADR	UN 3265 8/PG 2
WGK Germany	3
F	19
Hazard Note	Corrosive/Lachrymator
TSCA	Yes
HazardClass	8
PackingGroup	III
HS Code	29171900

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English
ALFA	English

DIETHYL BROMOMALONATE Usage And Synthesis

Chemical Properties	CLEAR COLOURLESS TO SLIGHTLY YELLOW LIQUID
Uses	Diethyl Bromomalonate is a chemical constituent of the asymmetric cyclopropanation of chalcones. Also used in the preparation of nanaplatforms for NIR imaging-guided photodynamic therapy of cancer cel ls.
Uses	Diethyl bromomalonate is used in perfumes. It is also used to synthesize other compounds such as barbiturates, artificial flavorings, vitamin B1, and vitamin B6.
Purification Methods	Purify the ester by fractional distillation in a vacuum. IR: max 1800 and 1700cm-1 [Abramovitch Can J Chem 37 1146 1959, Bretschneider & Karpitschka Monatsh Chem 84 1091 1053]. [Beilstein 2 IV 1904.]

DIETHYL BROMOMALONATE Preparation Products And Raw materials

Raw materials

Ethyl acetate-->Tetrahydrofuran-->PETROLEUM ETHER-->Sodium carbonate-->Government regulation-->Carbon tetrachloride-->Diethyl malonate

Preparation Products

3-Methylbenzofuran-2-carboxylic acid-->Benzofuran-2-carboxylic acid-->5-METHOXYBENZOFURAN-2-BORONIC ACID-->2-ETHOXYCARBONYL-3-COUMARANONE-->1-Oxo-1H-isochromene-3-carboxylic Acid-->Diethyl allylmalonate-->ETHYL 5-NITROBENZOFURAN-2-CARBOXYLATE-->Diethyl chloromalonate-->5-NITROBENZOFURAN-2-CARBOXYLIC ACID-->ETHYL(5-BROMOBENZOFURAN)-2-CARBOXYLATE-->Ethyl 4-hydroxy-2-(pyridin-3-yl)thiazole-5-carboxylate-->ETHYL 4-HYDROXY-2-(4-METHYLPHENYL)-1,3-THIAZOLE-5-CARBOXYLATE

Bromo-PEG2-acid BROMOTRIS(TRIPHENYLPHOSPHINE)COPPER(I)& N-Bromoisocyanuric acid monosodium salt Methyl Bromopyruvate NEOPENTYLBORONIC ACID METHYL 2-BROMO-3-METHOXYPROPIONATE 3-METHOXYPROPIONIC ACID ETHYL ESTER Methyl 2-bromopropionate (S)-(-)-2-Bromo-3-hydroxypropanoicacid Ethyl 2-bromopropionate 1-Bromo-2-methoxyethane (S)-(-)-2-BROMOPROPIONIC ACID (R)-(+)-2-BROMOPROPIONIC ACID DIMETHYL BROMOMALONATE DIETHYL 2-BROMO-2-FLUORO-MALONATE DIETHYL BROMOMALONATE (BROMOMALONIC ACID DIETHYL ESTER) DIETHYL DIBROMOMALONATE DIETHYL BROMOMALONATE

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