ChemicalBook Product Catalog Analytical Chemistry Standard Pharmaceutical Impurity Reference Standards (1S,2S,3R,5S)-PinanediolN-BOC-L-phenylalanine-L-leucine boronate

(1S,2S,3R,5S)-PinanediolN-BOC-L-phenylalanine-L-leucine boronate

(1S,2S,3R,5S)-PinanediolN-BOC-L-phenylalanine-L-leucine boronate Basic information
Product Name:(1S,2S,3R,5S)-PinanediolN-BOC-L-phenylalanine-L-leucine boronate
Synonyms:(1S,2S,3R,5S)-PinanediolN-BOC-L-phenylalanine-L-leucine boronate;tert-butyl 4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)-benzoyl)piperazin-1-carboxylate;Bortezomib Impurity 53;Carbamic acid, N-[(1S)-2-[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester
CAS:1187479-72-6
MF:C29H45BN2O5
MW:512.49
EINECS:
Product Categories:
Mol File:1187479-72-6.mol
(1S,2S,3R,5S)-PinanediolN-BOC-L-phenylalanine-L-leucine boronate Structure
(1S,2S,3R,5S)-PinanediolN-BOC-L-phenylalanine-L-leucine boronate Chemical Properties
Boiling point 635.7±55.0 °C(Predicted)
density 1.10±0.1 g/cm3(Predicted)
pka11.39±0.46(Predicted)
Safety Information
MSDS Information
(1S,2S,3R,5S)-PinanediolN-BOC-L-phenylalanine-L-leucine boronate Usage And Synthesis
UsesN-[(1S)-2-[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-Carbamic Acid 1,1-Dimethylethyl Ester is an intermediate in the synthesis of bortezomib (B675700).Bortezomib is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer.
(1S,2S,3R,5S)-PinanediolN-BOC-L-phenylalanine-L-leucine boronate Preparation Products And Raw materials
4,6-Methano-1,3,2-benzodioxaborole,2-[(1S)-1-chloro-3-Methylbutyl]hexahydro-3a,5,5-triMethyl-,(3aS,4S,6S,7aR)- Bortezomib Impurity 8 Isovaleraldehyde Bortezomib Impurity 56 HCl Bortezomib Impurity 60 Bortezomib Impurity 47 HCl (S)-(+)-PINANEDIOL (DICHLORMETHYL)BORONATE Bortezomib Impurity 32 (S,E)-N-(1-((3-methylbut-1-en-1-yl)amino)-1-oxo-3-phenylpropan-2-yl) pyrazine-2-carboxamide (IS,2S,3R,5S)-Pinanediol-L-phenylalanine-L-leucine boronate, HCl salt Desisobutyl-n-butyl BortezoMib Bortezomib Impurity 9 Bortezomib Impurity 52 3,6-Dibenzylhexahydropyrazine-2,5-dione Bortezomib intermediates II BORTEZOMIB-PINANEDIOL (R)-3-phenyl-2-(pyrazine-2-carboxaMido)propanoic acid Bortezomib Impurity 57
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