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| | Tubulysin A,TubA Basic information |
| Product Name: | Tubulysin A,TubA | | Synonyms: | TubA;Tubulysin A;Tubulysin A,TubA;Tubulysins A;CS-1324;Benzenepentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl][(3-methyl-1-oxobutoxy)methyl]amino]pentyl]-4-thiazolyl]carbonyl]amino]-4-hydroxy-α-methyl-, (αS,γR)-;(2S,4R)-4-[[2-[(1R,3R)-1-acetyloxy-4-methyl-3-[3-methylbutanoyloxymethyl-[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]amino]pentyl]-1,3-thiazole-4-carbonyl]amino]-5-(4-hydroxyphenyl)-2-methylpentanoicaci | | CAS: | 205304-86-5 | | MF: | C43H65N5O10S | | MW: | 844.07 | | EINECS: | | | Product Categories: | | | Mol File: | 205304-86-5.mol |  |
| | Tubulysin A,TubA Chemical Properties |
| Melting point | 106-108 °C(Solv: methanol (67-56-1); water (7732-18-5)) | | Boiling point | 979.9±65.0 °C(Predicted) | | density | 1.195±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | organic solvents: soluble | | pka | 4.52±0.23(Predicted) | | form | film | | color | colorless or white |
| | Tubulysin A,TubA Usage And Synthesis |
| Uses | Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. | | Definition | ChEBI: Tubulysin A is a diester and a carboxylic acid. | | Biochem/physiol Actions | Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysins are cytotoxic peptides, which include 9 members (A-I). Tubulysin A has potential application as an anticancer agent. It arrests cells in the G2/M phase. Tubulysin A inhibits polymerization more efficiently than vinblastine and induces depolymerization of isolated microtubules. Tubulysin A has potent cytostatic effects on various tumor cell lines with IC50 in the picomolar range. |
| | Tubulysin A,TubA Preparation Products And Raw materials |
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