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| Fmoc-L-glutamic acid 5-tert-butyl ester Basic information |
| Fmoc-L-glutamic acid 5-tert-butyl ester Chemical Properties |
Melting point | 83-90 °C | alpha | -4.5 º (c=1, 80% acetic acid) | Boiling point | 633.5±55.0 °C(Predicted) | density | 1.232±0.06 g/cm3(Predicted) | refractive index | -4 ° (C=1, 80% AcOH) | storage temp. | Store below +30°C. | solubility | soluble in Methanol | pka | 3.70±0.10(Predicted) | form | powder to crystal | color | White to Almost white | optical activity | [α]20/D 5.0±2.0°, c = 1% in acetic acid: water (4:1) | BRN | 3636375 | InChIKey | OTKXCALUHMPIGM-FQEVSTJZSA-N | SMILES | C(O)(=O)[C@H](CCC(OC(C)(C)C)=O)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O | CAS DataBase Reference | 71989-18-9(CAS DataBase Reference) |
| Fmoc-L-glutamic acid 5-tert-butyl ester Usage And Synthesis |
Description | Fmoc-L-glutamic acid 5-tert-butyl ester is a Fmoc derivative with an N-substituted tert-butyl ester molecule. It is white or gray-white solid crystals at room temperature and pressure, poor solubility in water and insoluble in petroleum ether, but soluble in ethyl acetate, acetic acid and N,N-dimethylformamide. | Chemical Properties | White powder | Uses | Fmoc-Glu(OtBu)-OH (Fmoc-L-glutamic acid 5-tert-butyl ester) can be employed as a:
- Ligand in the synthesis of cis-substituted cyclopropane carboxylic acids via C-H activation of cyclopropane carboxamides using Pd catalyst.
- Linker in the preparation of multi-small molecule-conjugated PTX (paclitaxel) derivatives.
It can be also used as a building block in the preparation of stapled α-helical peptides , and peptide C-terminal thioesters . | General Description | The product number for this product was previously 04-12-1020.
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| Fmoc-L-glutamic acid 5-tert-butyl ester Preparation Products And Raw materials |
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