(-)-Nebivolol

(-)-Nebivolol Basic information
Product Name:(-)-Nebivolol
Synonyms:(aS,a,2R,2)-a,a[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol];(2R)-2-[(S)-1-Hydroxy-2-[[(S)-2-hydroxy-2-[[(2S)-3,4-dihydro-6-fluoro-2H-1-benzopyran]-2-yl]ethyl]amino]ethyl]-6-fluoro-3,4-dihydro-2H-1-benzopyran;[2R,2'S,αS,α'S,(-)]-α,α'-[Iminobis(methylene)]bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol);(αS,α'S,2R,2'S)-α,α'-[IMinobis(Methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-Methanol];[2S-[2R*[R*[R*(S*)]]]]-α,α'-[IMinobis(Methylene)]bis[6-fluoro-3,4-dihydro- 2H-1-benzopyran-2-Methanol;Levonebivolol;Nebivolol IMpurity A (L-Nebivolol);l-Nebivolol
CAS:118457-16-2
MF:C22H25F2NO4
MW:405.43
EINECS:
Product Categories:Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:118457-16-2.mol
(-)-Nebivolol Structure
(-)-Nebivolol Chemical Properties
Melting point 135-137°C
Boiling point 600.5±55.0 °C(Predicted)
density 1.309±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility Chloroform (Slightly), Methanol (Slightly)
pka14.29±0.20(Predicted)
form Solid
color White to Off-White
Safety Information
MSDS Information
(-)-Nebivolol Usage And Synthesis
Chemical PropertiesOff-White Solid
Uses(-)-Nebivolol is a β1-Adrenergic blocker. Used as an antihypertensive.
UsesA β1-Adrenergic blocker. Used as an antihypertensive.
DefinitionChEBI: A 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol] that has (1S,1'S,2R,2'S)-configuration.
(-)-Nebivolol Preparation Products And Raw materials
Nebivolol Impurity 10 HCl (RS,SR) Nebivolol (R,R,S,R)-Isomer Nebivolol Impurity 12 HCl (RR,RR) (2S)-6-fluoro-2-(oxiran-2-yl)chromane (R)-6-Fluoro-2-[(R)-2-oxiranyl]chromane (2R)-rel-6-Fluoro-3,4-dihydro-2-(2R)-2-oxiranyl-2H-1-benzopyran D-Nebivolol,hydrochloride(1:1) 4-Hydroxy Nebivolol, Hydrochloride Hydrate (Mixture of Diastereomers) Nebivolol 3-(4-fluorophenoxy)propan-1-amine [3-(4-FLUOROPHENOXY)PROPYL]METHYLAMINE (-)-Nebivolol 6-FLUOROCHROMAN

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