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thenalidine

thenalidine Basic information
Product Name:thenalidine
Synonyms:thenalidine;1-Methyl-4-[phenyl(2-thienylmethyl)amino]piperidine;Sandostene;Thenalidin;Thenophenopiperidine;Thenaldine;4-Piperidinamine, 1-methyl-N-phenyl-N-(2-thienylmethyl)-;thenalidine USP/EP/BP
CAS:86-12-4
MF:C17H22N2S
MW:286.43
EINECS:201-651-5
Product Categories:
Mol File:86-12-4.mol
thenalidine Structure
thenalidine Chemical Properties
Melting point 95-97°
Boiling point bp0.02 158-160°
density 1.140±0.06 g/cm3(Predicted)
pkapKa 3.36±0.06(H2O t undefined I = 0.30 (NaCl)) (Uncertain);8.39±0.07(H2O t undefined I = 0.30 (NaCl)) (Uncertain)
Safety Information
MSDS Information
thenalidine Usage And Synthesis
UsesThenalidine is an antihistamine that has anticholinergic properties which is used as an antipruritic drugs.
DefinitionChEBI: Thenalidine is a dialkylarylamine and a tertiary amino compound.
Brand nameSanbosten.
World Health Organization (WHO)Thenalidine, a piperidine antihistamine, was introduced in 1953 for the management of dermatologic and allergic conditions. By 1958 its use had been associated with cases of severe neutropenia, two of them fatal, which led to its withdrawal in the United States of America and subsequently in the United Kingdom. Over the next fifteen years, continued reports of its association with cases of neutropenia resulted in further withdrawals in many countries. It is apparently still available, however, in some combination products.
N-(1-ACETYL-2,3-DIHYDRO-(1H)-INDOL-6-YL)-N-(1-BENZYLPIPERIDIN-4-YL)THIOPHENE-2-CARBOXAMIDE N-(1-ACETYLPIPERIDIN-4-YL)-N-(2-TERT-BUTYL-(1H)-INDOL-5-YL)THIOPHENE-2-CARBOXAMIDE N-(1-ACETYL-2,3-DIHYDRO-(1H)-INDOL-5-YL)-N-(1-ACETYLPIPERIDIN-4-YL)THIOPHENE-2-CARBOXAMIDE N-(1-ACETYLPIPERIDIN-4-YL)-N-(2,3-DIHYDRO-1-(METHYLSULPHONYL)-(1H)-INDOL-5-YL)THIOPHENE-2-CARBOXAMIDE N-(1-BENZYLPIPERIDIN-4-YL)-N-(2,3-DIHYDRO-1-(METHYLSULPHONYL)-(1H)-INDOL-5-YL)THIOPHENE-2-CARBOXAMIDE N-(1-ACETYL-2,3-DIHYDRO-(1H)-INDOL-6-YL)-N-(1-METHYLPIPERIDIN-4-YL)THIOPHENE-2-CARBOXAMIDE thenalidine tartrate N-[2-METHYL-1H-INDOL-5-YL]-N-[1-(2-PHENYLETHYL)PIPERIDIN-4-YL]THIOPHENE-2-CARBOXAMIDE N-(1-ACETYL-2,3-DIHYDRO-(1H)-INDOL-5-YL)-N-(1-BENZYLPIPERIDIN-4-YL)THIOPHENE-2-CARBOXAMIDE thenalidine N-(1-ACETYL-2,3-DIHYDRO-(1H)-INDOL-5-YL)-N-(1-PROPYLPIPERIDIN-4-YL)-THIOPHENE-2-CARBOXAMIDE
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