ChemicalBook Product Catalog Biochemical Engineering Amino Acids and Derivatives Aspartic acid derivatives N-Methyl-D-aspartic acid

N-Methyl-D-aspartic acid

N-Methyl-D-aspartic acid Basic information
Product Name:N-Methyl-D-aspartic acid
Synonyms:N-METHYL-D-ASPARAGINIC ACID;N-METHYL-D-ASPARTIC ACID;N-METHYL-D-ASPARTIC ACID HYDROCHLORIDE;N-ME-D-ASPARTIC ACID;N-ME-D-ASP-OH;N-ME-D-ASP-OH HCL;NMDA;H-D-MEASP-OH
CAS:6384-92-5
MF:C5H9NO4
MW:147.13
EINECS:227-012-0
Product Categories:Glutamate;amino acids;Glutamate receptor;Inhibitors;Pyridines
Mol File:6384-92-5.mol
N-Methyl-D-aspartic acid Structure
N-Methyl-D-aspartic acid Chemical Properties
Melting point 187-192 °C
alpha -28 º (c=1, HCl 6N)
Boiling point 267.21°C (rough estimate)
density 1.4285 (rough estimate)
refractive index -15 ° (C=2, H2O)
storage temp. Sealed in dry,Room Temperature
solubility Aqueous Acid (Slightly), DMSO (Slightly), Water (Slightly)
pka2.21±0.23(Predicted)
form solid
color white
Water Solubility slightly soluble
Sensitive Hygroscopic
Merck 14,6662
BRN 1724431
LogP1.390 (est)
CAS DataBase Reference6384-92-5(CAS DataBase Reference)
Safety Information
Safety Statements 22-24/25
WGK Germany 3
RTECS CI9457000
F 10
HS Code 29225090
MSDS Information
ProviderLanguage
(R)-2-(Methylamino)succinic acid English
SigmaAldrich English
ACROS English
N-Methyl-D-aspartic acid Usage And Synthesis
Chemical Propertieswhite to off-white crystalline powder
UsesNMDA agonist
UsesNMDA（N-Methyl-D-aspartic acid）is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.
DefinitionChEBI: An aspartic acid derivative having an N-methyl substituent and D-configuration.
General DescriptionN-Methyl-D-aspartic acid (NMDA) is an endogenously generated molecule in rat nervous system and endocrine glands. NMDA is present at low level (nmol/g) in the adenohypophysis, hypothalamus, brain, and testis. NMDA is derived from D-Asp by an S-adenosylmethionine-dependent enzyme also referred to as NMDA synthase.
Biological ActivityPrototypic NMDA receptor agonist. Also available as part of the Mixed NMDA Receptor Tocriset™ .
Biochem/physiol ActionsExcitotoxic amino acid. Prototypic agonist at the NMDA-type glutamate receptor that regulates ion channels; important in long-term potentiation, ischemia, and epilepsy.
storageRoom temperature
references[1] watkins jc, jane de. the glutamate story. br j pharmacol. 2006 jan;147 suppl 1:s100-8.
[2] lafon-cazal m, pietri s, culcasi m, bockaert j. nmda-dependent superoxide production and neurotoxicity. nature. 1993 aug 5;364(6437):535-7.
N-Methyl-D-aspartic acid Preparation Products And Raw materials
LABOTEST-BB LT00455678 Methylparaben Methyl Boc-D-aspartic acid 4-cyslohexyl ester GLYCYL-D-ASPARTIC ACID N-METHYL-DL-ASPARTIC ACID N-Benzyloxycarbonyl-D-aspartic acid Diethyl succinosuccinate Kresoxim-methyl Boc-D-aspartic acid 4-benzyl ester Methanol Tris(hydroxymethyl)aminomethane Methyl acrylate N-Methyl-D-aspartic acid meso-2,3-Dibromosuccinic acid Methyl bromide METSULFURON METHYL N,N-Dimethyl-1,4-phenylenediamine
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