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| | Pyridoxine hydrochloride Chemical Properties |
| Melting point | 214-215 °C(lit.) | | density | 1.2784 (rough estimate) | | vapor density | 7.1 (vs air) | | refractive index | 1.5800 (estimate) | | Fp | 9℃ | | storage temp. | room temp | | solubility | H2O: 0.1 g/mL at 20 °C, clear, colorless | | form | Crystalline Powder | | color | White to almost white | | PH Range | 3.2 | | Water Solubility | 0.1 g/mL (20 ºC) | | Sensitive | Light Sensitive | | Merck | 14,7982 | | BRN | 3632435 | | BCS Class | 1 | | Stability: | Stable. Protect from air and light. | | LogP | -1.098 (est) | | CAS DataBase Reference | 58-56-0(CAS DataBase Reference) | | EPA Substance Registry System | 5-Hydroxy-6-methyl-3,4-pyridinedimethanol, hydrochloride (58-56-0) |
| | Pyridoxine hydrochloride Usage And Synthesis |
| Nutrition supplements | Pyridoxine hydrochloride is the hydrochloride salt of Vitamin B6. Vitamin B6 (B6) is a water-soluble vitamin, which can be found in various foods such as fish, poultry, whole grains, legumes, banana, nuts, and sesame.Vitamin B6 has an important role in the metabolism of amino acids as a coenzyme, pyridoxal 5'-phosphate.
B6 may exert an anticolon tumor effect by the protection of the colon epithelium from damage in rats treated with 1,2-dimethylhidrazine (DMH) and to decreased lithocholic acid, a colon carcinogen. Vitamin B6 may prevent such diseases by lowering inflammation.
| | Chemical Properties | White or almost white, crystalline powder. | | Uses | Pyridoxine is one of the vitamins of the B6 complex; present in many foodstuffs (yeast, liver and cereals). Pyridoxine has a role in transporting protein Bsu1, Pyridoxine contributes to thiamine uptak
e; characterization of thiamine (vitamin B1) transporter Thi9 from Schizosaccharomyces pombe. | | Uses | Pyridoxine Hydrochloride is an acid form of vitamin b6, a water-
soluble vitamin. it is soluble in water, and slightly soluble in alco-
hol. it is slowly affected by sunlight and is reasonably stable in air.
it has a ph of 2.3–3.5. it is also termed vitamin b6 hydrochloride.
see pyridoxine. | | Definition | ChEBI: Pyridoxine hydrochloride is the hydrochloride salt of pyridoxine. It is a hydrochloride and a vitamin B6. It contains a pyridoxine. | | Brand name | Hexa-Betalin (Lilly). | | General Description | Vitamin B6 has six forms namely, pyridoxal, pyridoxine, pyridoxamine, pyridoxamine 5′-phosphate, pyridoxine 5′-phosphate and pyridoxal 5′-phosphate. Pyridoxine is a is a water-soluble vitamin and a pyrimidine derivative of vitamin B6. It is considered heat and acid stable. | | Biochem/physiol Actions | Vitamin B6 is an essential coenzyme for amino acid, carbohydrate and lipid metabolism. Pyridoxine serves as a primary source in multivitamins. Pyridoxine deficiency is associated with peripheral neuropathy. | | Clinical Use | Vitamin B6 | | Safety Profile | Poison by intravenous route. Moderately toxic by ingestion, intramuscular, and subcutaneous routes. Human reproductive effects by ingestion and intramuscular routes: postpartum changes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl. | | Metabolism | Pyridoxine is metabolised to its active form pyridoxamine
phosphate. It is stored mainly in the liver where there
is oxidation to 4-pyridoxic acid and other inactive
metabolites which are excreted in the urine. | | Purification Methods | Purify the vitamin by recrystallisation from EtOH/Me2CO, n-BuOH or MeOH/Et2O. Its solubility in H2O is 22%, and in EtOH it is 1.1%. It is insoluble in Et2O and CHCl3. Acidic aqueous solutions are stable at 120o/30minute. The free base has m 159-160o after recrystallisation from Me2CO and sublimation at 140-145o/0.0001mm. It has UV max at 290nm ( 84,000), 253 and 325nm ( 3,700 and 7,100) in 0.1N aqueous HCl. [Khua & Wendt Chem Ber 71 780 1938, 72 311 1939, Harris & Folkers J Am Chem Soc 61 1242 1939, Harris et al. J Am Chem Soc 62 3198 1940, Beilstein 21/5 V 492.] |
| | Pyridoxine hydrochloride Preparation Products And Raw materials |
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