ChemicalBook Product Catalog API Antipyretic analgesics Nonsteroidal Anti-Inflammatory Drugs (NSAIDS) CINCHOPHEN

CINCHOPHEN

CINCHOPHEN Basic information
Product Name:CINCHOPHEN
Synonyms:LABOTEST-BB LT00453769;RHEUMIN;RHEMATAN;2-PHENYLQUINOLINE-4-CARBOXYLIC ACID;2-PHENYLQUINOLEINE-4-CARBOXYLIC ACID;2-PHENYLCINCHONINIC ACID;2-PHENYL-4-QUINOLINECARBOXYLIC ACID;CINCHOPHEN
CAS:132-60-5
MF:C16H11NO2
MW:249.26
EINECS:205-067-1
Product Categories:ATOPHAN;API intermediates;Quinolinecarboxylic Acids, etc.;Quinolines
Mol File:132-60-5.mol
CINCHOPHEN Structure
CINCHOPHEN Chemical Properties
Melting point 214-215 °C (lit.)
Boiling point 392.37°C (rough estimate)
density 1.1426 (rough estimate)
refractive index 1.5300 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility alcohol: soluble1g in 120ml(lit.)
pka0.96±0.10(Predicted)
form Solid
color White
Water Solubility Insoluble in water
Sensitive Light Sensitive
Merck 14,2288
BRN 192803
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 36/37/39-26
RIDADR 3249
WGK Germany 3
RTECS GD4025000
HazardClass 6.1(b)
PackingGroup III
HS Code 29334990
Hazardous Substances Data132-60-5(Hazardous Substances Data)
ToxicityLD50 oral in dog: 1250mg/kg
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
CINCHOPHEN Usage And Synthesis
Chemical PropertiesBEIGE POWDER
Usesanalgesic, antipyretic, antiinflammatory
UsesCinchophen and its derivatives can show antipyretic, analgesic, anti-oxidative, and anti-inflammatory properties.
DefinitionChEBI: 2-phenyl-4-quinolinecarboxylic acid is a member of quinolines.
Brand nameAglophenyl;Alcophenyl;Artexin;Atophan;Cefeno;Cinchophene;Cinconal;Cincosal;Fenofan;Iriphan;Mylofanol;Mylophanol;Phenoquin;Rhematan;Tervalon;Traubofan;Viophan.
World Health Organization (WHO)Cinchophen, an analgesic and antipyretic, was formerly available in preparations for the treatment of gout. Its use was associated with adverse effects including hepatitis, cirrhosis, skin lesions and angioneurotic oedema. WHO has no information to suggest that preparations containing cinchophen remains commercially available.
Purification MethodsIt crystallises from EtOH (ca 20mL/g), in several modifications with m 196o and 216o(subliming at 65o). [Beilstein 22 H 103, 22 II 518, 22 II 70, 22 III/IV 1358.]
CINCHOPHEN Preparation Products And Raw materials
Raw materialsAcetone-->Sodium formate-->Isatin-->Benzoylformic acid
2-P-TOLYL-QUINOLINE-4-CARBOXYLIC ACID 2-(4-BROMO-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID Cinchophen hydriodide 6-BROMO-2-P-TOLYL-QUINOLINE-4-CARBOXYLIC ACID 2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID METHYL ESTER 2-(4-METHOXY-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID oxycinchophen Methyl 4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinecarboxylate 2-(3-CARBOXY-4-HYDROXYPHENYL) QUINOLINE-4-CARBOXYLIC ACID NEOCINCHOPHEN 6-CHLORO-2-(4-CHLOROPHENYL)-4-QUINOLINE CARBOXYLIC ACID 2-(3-AMINO-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID 2-BIPHENYL-4-YL-QUINOLINE-4-CARBOXYLIC ACID 2-(4-CHLORO-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID 6-METHOXY-2-PHENYL-4-QUINOLINECARBOXYLIC ACID 2-(4-METHOXYPHENYL)-7-METHYLQUINOLINE-4-CARBOXYLIC ACID CINCHOPHEN 2-(4-AMINO-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID
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