ChemicalBook Product Catalog Biochemical Engineering Amino Acids and Derivatives BOC-amino acid 4-Amino-1-Boc-piperidine

4-Amino-1-Boc-piperidine

4-Amino-1-Boc-piperidine Basic information
Product Name:4-Amino-1-Boc-piperidine
Synonyms:1-PIPERIDINECARBOXYLIC ACID, 4-AMINO-,1,1-DIMETHYLETHYL ESTER;1-N-BOC-4-AMINOPIPERIDINE;1-T-BUTOXYCARBONYL-4-AMINOPIPERIDINE;1-tert-Butoxycarbonyl-4-amino-piperidine;1-BOC-4-PIPERIDINAMINE;1-BOC-4-AMINOPIPERIDINE;1-BUTYLOXYCARBONYL-4-AMINO-PIPERIDINE;4-AMINO-1-BOC-PIPERIDINE
CAS:87120-72-7
MF:C10H20N2O2
MW:200.28
EINECS:1312995-182-4
Product Categories:Piperazine;Pyrans, Piperidines & Piperazines;Amines;blocks;Piperidines, Piperidones, Piperazines;pharmacetical;AMINOACID;Amines and Anilines;Pyrans, Piperidines &Piperazines;API intermediates;Piperidines;87120-72-7
Mol File:87120-72-7.mol
4-Amino-1-Boc-piperidine Structure
4-Amino-1-Boc-piperidine Chemical Properties
Melting point 50°C
Boiling point 80/0.037mm
density 1.041±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
pka10.10±0.20(Predicted)
form Crystalline Powder, Crystals and/or Chunks
color White to pale yellow to beige
Water Solubility Insoluble in water.
Sensitive Air Sensitive
InChIInChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-6-4-8(11)5-7-12/h8H,4-7,11H2,1-3H3
InChIKeyLZRDHSFPLUWYAX-UHFFFAOYSA-N
SMILESN1(C(OC(C)(C)C)=O)CCC(N)CC1
CAS DataBase Reference87120-72-7(CAS DataBase Reference)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-37/38-41-36/37/38-20/21/22-20/21/2236/37/38
Safety Statements 26-36/37/39-22-222636/37/39
RIDADR 3259
WGK Germany 2
F 10-34
Hazard Note Irritant
TSCA N
HazardClass 8
PackingGroup Ⅲ
HS Code 29339900
MSDS Information
ProviderLanguage
SigmaAldrich English
4-Amino-1-Boc-piperidine Usage And Synthesis
Chemical Propertieswhite to light yellow crystal powder
Uses4-Amino-1-Boc-piperidine is a chemical reagent used in the preparation of pharmaceutical compounds. Used in the synthesis of bromodomain inhibitors as well as HepG2 cell cycle inhibitors used in anti-tumor therapy. Also employed in a microwave-assisted solid-phase synthesis of N-substituted piperidines via direct annulation of primary amines with resin-bound dimesylates.
Uses4-Amino-1-Boc-piperidine is a potent inhibitor of the CCR5 receptor. It is an x-ray crystal structure with a hydroxide solution that inhibits the growth of cancer cells. The inhibitor binding site for 4-Amino-1-Boc-piperidine was determined to be the CCR5 receptor, which is located on the surface of hematopoietic cells. The compound has been shown to inhibit human T lymphocyte proliferation in vitro and inhibit HIV replication in infected patients. 4-Amino-1-Boc-piperidine is able to inhibit the growth of cancer cells by blocking the production of cytokines, such as interleukin 2, that are needed for cell division and growth.
Application 4-Amino-1-Boc-piperidine is a pharmaceutical intermediate is applied in the treatment of anti-tumor and other drugs. It is an important fine chemical intermediate and has a wide range of uses in the pharmaceutical industry.
TERT-BUTYL 4-(4-METHOXYANILINO)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 4,4'-Diaminodiphenylsulfone tert-butyl 4-amino-1-piperidinecarboxylate hydrochloride 1-Aminopiperidine 4-(FMOC-AMINO)-1-BOC-PIPERIDINE-4-CARBOXYLIC ACID,FMOC-4-AMINO-1-BOC-PIPERIDINE-4-CARBOXYLIC ACID 4-AMINO-1-BOC-PIPERIDINE-4-CARBOXYLIC ACID BOC-3-CARBOXYMETHYL-1-PHENYL-1,3,8-TRIAZASPIRO[4 5]DECAN-4-ONE Glycine FMOC-N-(1-BOC-PIPERIDIN-4-YL)-GLYCINE TERT-BUTYL 4-(4-CHLOROANILINO)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE L-N-[(4'-BOC)PIPERIDINO]PROLINE 4-Aminoantipyrine Haloperidol AMINO ACIDS 4-Amino-1-Boc-piperidine DROPERIDOL DI-TERT-BUTYL ETHER 4-Dimethylaminopyridine
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