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| | Pinacolborane Basic information |
| Product Name: | Pinacolborane | | Synonyms: | Pinacolatoborane;TetraMethyl-1,3,2-dioxab;Pinacolborane, 97%, stabilized;4,4,5,5-TetraMethyl-1,3,2-dioxaborolane 97%;4,4,5,5-TetraMethyl-1,3,2-dioxaborolane solution 1.0 M in THF;Pinacolborane
(4,4,5,5-Tetramethyl-1,3,2-dioxaborolane);4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE;PINACOLBORANE | | CAS: | 25015-63-8 | | MF: | C6H13BO2 | | MW: | 127.98 | | EINECS: | 607-485-3 | | Product Categories: | Boron Derivatives;Heterocycles | | Mol File: | 25015-63-8.mol |  |
| | Pinacolborane Chemical Properties |
| Boiling point | 42-43 °C50 mm Hg(lit.) | | density | 0.882 g/mL at 25 °C(lit.) | | vapor pressure | 29-119.9hPa at 20-50℃ | | refractive index | n20/D 1.396(lit.) | | Fp | 41 °F | | storage temp. | 2-8°C | | solubility | Miscible with ether, dichloromethane, tetrahydrofuran and organic solvents. | | form | Liquid | | color | Clear colorless to light yellow | | Specific Gravity | 0.882 | | Sensitive | Air Sensitive | | BRN | 7802871 | | Stability: | Air Sensitive, Hygroscopic, Moisture Sensitive | | CAS DataBase Reference | 25015-63-8(CAS DataBase Reference) |
| | Pinacolborane Usage And Synthesis |
| Chemical Properties | Clear colorless liquid | | Uses | Pinacolborane is used for synthesis of unsymmetrical biaryls via aromatic C-H borylation-cross-coupling sequence.
| | Uses | Pinacolborane is used as a precursor of boronic esters by hydroboration or coupling reactions. It acts as a monofunctional hydroborating agent. It is used in the synthesis of unsymmetrical biaryls through aromatic C-H borylation-cross-coupling sequence. It is involved in the preparation of 4,4,5,5-tetramethyl-2-thiophen-2-yl-[1,3,2]dioxaborolane by reacting with 2-iodo-thiophene. Further, it is used to prepare vinylboronates by palladium-catalyzed coupling with alkenyl triflates and iodides. |
| | Pinacolborane Preparation Products And Raw materials |
| Raw materials | Dichloromethane-->Pinacol-->Borane-methyl sulfide complex | | Preparation Products | 3-MORPHOLINOPHENYLBORONIC ACID PINACOL ESTER-->2-Ethoxycarbonylphenylboronic acid pinacol ester-->4-Aminophenylboronic acid pinacol ester-->4-Hydroxyphenylboronic acid pinacol ester-->BISPINACOLATOBIBORATE-->1,3,2-Dioxaborolane, 4,4,5,5-tetramethyl-2-[(4-methylphenyl)methoxy]--->1,3,2-Dioxaborolane, 4,4,5,5-tetramethyl-2-(phenylmethoxy)--->4-Nitrophenylboronic acid pinacol ester-->1-Boc-pyrazole-4-boronic acid pinacol ester-->2-AMINO-5-FLUOROPHENYL BORONIC ACID PINACOL ESTER-->2-AMINO-5-FLUOROBENZENEBORONIC ACID-->3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-->(S)-methyl 2-(tert-butoxycarbonylamino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate-->2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane-->2-(3,4-Dihydro-2H-pyran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane-->4-(N-METHYLAMINO)PHENYLBORONIC ACID, PINACOL ESTER |
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