Dibutyl sebacate

Dibutyl sebacate Basic information
Product Name:Dibutyl sebacate
Synonyms:DIBUTYL SEBACATE, TECH.;dibutyl-1,10-decanedioate;Decanedioic acid dibutyl;Dibutyl sebacate,Sebacic acid dibutyl ester;Dibutyl Sebacate (AS);Dibutyl Sebacate (1 mL);Dibutyl sebacinate;dibutyl1,8-octanedicarboxylate
CAS:109-43-3
MF:C18H34O4
MW:314.46
EINECS:203-672-5
Product Categories:pharmacetical;Piperazine derivates;Fatty Acid Esters (Plasticizer);Functional Materials;Plasticizer;bc0001
Mol File:109-43-3.mol
Dibutyl sebacate Structure
Dibutyl sebacate Chemical Properties
Melting point 205 °C (dec.)(lit.)
Boiling point 178-179 °C3 mm Hg(lit.)
density 0.94
vapor pressure 0.001Pa at 25℃
refractive index n20/D 1.441(lit.)
FEMA 2373 | DIBUTYL SEBACATE
Fp >230 °F
storage temp. Sealed in dry,Room Temperature
solubility hexane, toluene, ethanol and acetone: soluble
form Liquid
Specific Gravity0.937 (20/4℃)
color Clear
Odorat 100.00 %. faint fruity oily
Odor Typefruity
Water Solubility 50mg/L(temperature not stated)
JECFA Number625
BRN 1798308
LogP6.30
CAS DataBase Reference109-43-3(CAS DataBase Reference)
NIST Chemistry ReferenceDi-n-butyl sebacate(109-43-3)
EPA Substance Registry SystemDibutyl sebacate (109-43-3)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 40-36/37/38
Safety Statements 36/37-36-26
WGK Germany 3
RTECS VS1150000
TSCA Yes
HS Code 29171390
Hazardous Substances Data109-43-3(Hazardous Substances Data)
ToxicityLD50 oral in rat: 14870mg/kg
MSDS Information
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Dibutyl sebacate Usage And Synthesis
Chemical Propertiesclear liquid
Chemical PropertiesDibutyl sebacate is a clear, colorless, oily liquid with a bland to slight butyl odor.
UsesDibutyl sebacate (DBS) is a dibutyl ester of sebacic acid. Dibutyl sebacate can be used for plastics in use in the food packaging industry, in plastics used for medical devices, and for pharmaceutical applications. Dibutyl sebacate is also used as a desensitizer in Otto fuel II, a torpedo monopropellant.
UsesDibutyl sebacate has been used as a plasticizer to prepare free ethylcellulose films. It can be utilized as a core in liquid-core capsules with cross-linked alginate/polyacrylamide membrane prepared via co-extrusion jet-break-up method for the extraction of the pesticide, atrazine.
PreparationBy distillation of sebacic acid with butyl alcohol in the presence of concentrated HCl in benzene solution or by reacting butyl alcohol and sebacyl chloride
Production MethodsDibutyl sebacate is manufactured by the esterification of n-butanol and sebacic acid in the presence of a suitable catalyst, and by the distillation of sebacic acid with n-butanol in the presence of concentrated acid.
DefinitionChEBI: Dibutyl decanedioate is a fatty acid ester.
General DescriptionPharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Dibutyl sebacate is a commonly used plasticizer, which can be synthesized by the reaction of butyl alcohol and sebacyl chloride or by the distillation of sebacic acid with butyl alcohol in the presence of concentrated hydrochloric acid in benzene solution.
Flammability and ExplosibilityNonflammable
Pharmaceutical ApplicationsDibutyl sebacate is used in oral pharmaceutical formulations as a plasticizer for film coatings on tablets, beads, and granules, at concentrations of 10–30% by weight of polymer. It is also used as a plasticizer in controlled-release tablets and microcapsule preparations.
Dibutyl sebacate is also used as a synthetic flavor and flavor adjuvant in food products;for example,up to 5ppm is used in ice cream and nonalcoholic beverages.
Safety ProfileMddly toxic by ingestion. Experimental reproductive effects. Combustible liquid when exposed to heat or flame; can react with oxidzing materials. To fight fire, use CO2 position it emits acrid smoke and fumes. See also ESTERS and n-BUTYL. ALCOHOL.
SafetyDibutyl sebacate is used in cosmetics, foods, and oral pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material. Following oral administration, dibutyl sebacate is metabolized in the same way as fats. In humans, direct eye contact and prolonged or repeated contact with the skin may cause very mild irritation. Acute animal toxicity tests and long-term animal feeding studies have shown no serious adverse effects to be associated with orally administered dibutyl sebacate.
LD50 (rat, oral): 16g/kg
storageDibutyl sebacate should be stored in a closed container in a cool, dry location. Dibutyl sebacate is stable under the recommended storage conditions and as used in specified applications under most conditions ofuse.Asanester,dibutylsebacatemayhydrolyzeinthe presence of water at high or low pH conditions.
IncompatibilitiesDibutyl sebacate is incompatible with strong oxidizing materials and strong alkalis.
Regulatory StatusIncluded in the FDA Inactive Ingredients Database (oral capsules, granules, film-coated, sustained action, and tablets). Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Dibutyl sebacate Preparation Products And Raw materials
Raw materialstert-Butanol-->Castor oil-->Sebacic acid-->Sebacoyl chloride
Decanedihydrazide DIBUTYL SEBACATE SOLUTION 5000UG/ML IN METHYLENE CHLORIDE 5X1ML SCHIFF'S REAGENT PARAROSANILINE CHLORIDE Poly(maleicanhydride-acrylicacidcopolymer) DIDECYL SEBACATE DINONYL SEBACATE Dibutyl Sebacate(DBS) DI-ISO-OCTYL SEBACATE Bis-(1-octyloxy-2,2,6,6-tetramethyl-4-piperidinyl) sebacate DITRIDECYL SEBACATE ETHYLATED HEXAMETHYL PARAROSANILINE Dimethyl sebacate dioctyl succinate PARAROSANILINE,PARAROSANILINE BASE,PARAROSANILINE FREE BASE (C.I. 42500) Pararosaniline (Feulgen) Diisooctyl sebacate PARAROSANILINE SOLUTION Dibutyl sebacate (DBS) GOST 87 28

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