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| | BIS(2,2,2-TRIFLUOROETHYL) ETHER Basic information |
| Product Name: | BIS(2,2,2-TRIFLUOROETHYL) ETHER | | Synonyms: | Di(2,2,2-trifluroethyl)ether;Bis(2,2,2-trifluoroethyl) ether 99%;Bis(2,2,2-trifluoroethyl)ether99%;2,2,2-TRIFLUOROETHYL ETHER 99%;2,2,2-Trifluoroethyl ether, Flurothyl;1,1'-Oxybis(2,2,2-trifluoroethane);2,2,2-Trifluoroethyl ether,99%;1,1,1-Trifluoro-2-(2,2,2-trifluoroethoxy)ethane | | CAS: | 333-36-8 | | MF: | C4H4F6O | | MW: | 182.06 | | EINECS: | | | Product Categories: | IMITREX | | Mol File: | 333-36-8.mol |  |
| | BIS(2,2,2-TRIFLUOROETHYL) ETHER Chemical Properties |
| Melting point | 25°C | | Boiling point | 62-63 °C (lit.) | | density | 1.404 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.300(lit.) | | Fp | 35 °F | | storage temp. | Flammables area | | solubility | DMSO : ≥ 125 mg/mL (686.59 mM) | | form | clear liquid | | color | Colorless to Almost colorless | | Specific Gravity | 1.41 | | Merck | 14,4201 | | BRN | 1811927 | | CAS DataBase Reference | 333-36-8(CAS DataBase Reference) | | EPA Substance Registry System | HFE-356mff2 (333-36-8) |
| Hazard Codes | F,Xi,T | | Risk Statements | 11-36/37/38 | | Safety Statements | 16-26-36 | | RIDADR | UN 3271 3/PG 2 | | WGK Germany | 3 | | RTECS | KN3675000 | | Hazard Note | Flammable/Toxic/Convulsant | | HazardClass | 3.1 | | PackingGroup | II | | HS Code | 29091990 |
| | BIS(2,2,2-TRIFLUOROETHYL) ETHER Usage And Synthesis |
| Chemical Properties | clear colorless liquid | | Originator | Indoklon ,Ohio Medical, US ,1964 | | Uses | 5HT agonist | | Uses | Bis(2,2,2-trifluoroethyl) ether was used to diminish self-discharge of Li-S cells having both low- and high-sulfur-loading sulfur cathodes. | | Uses | Bis(2,2,2-trifluoroethyl) Ether is Prophylactic and/or therapeutic agent for Alzheimer''s disease. | | Definition | ChEBI: Flurotyl is an ether. | | Manufacturing Process | 23 parts of sodium metal were placed in 300 parts of dry dioxane in a reactor equipped with an agitator and reflux condenser. The dioxane was heated to reflux while stirring.150 parts of 2,2,2-trifluoroethanol were added very slowly in the period of about 1 hour, or until the sodium was all reacted, to form sodium 2,2,2-trifluoroethylate. 250 parts of 2,2,2-trifluoroethyl ptoluenesulfonate prepared by reacting 2,2,2-trifluoroethanol with p
Flurothyl toluenesulfonyl chloride were placed in another reactor and heated to about 160° to 185°C. The solution of sodium 2,2,2-trifluoroethylate in dioxane was added very slowly over a period of about 1? hours. Bis(2,2,2-trifluoroethyl) ether formed continuously and distilled from the reactor with the dioxane into a cooled receiving vessel. The condensed effluent from the reactor was fractionally distilled, yielding 46.5 parts of products boiling at 55° to 73°C.
The crude product was washed successively with concentrated HCl, 62% H2SO4,concentrated H2SO4 and 5% NaOH solution. It was dehydrated over a drying agent and then refractionated in a still. 20 parts of bis(2,2,2trifluoroethyl) ether were recovered (BP 62.5° to 63.5°C). | | Brand name | Indoklon (Ohmeda). | | Therapeutic Function | Central stimulant, Convulsant |
| | BIS(2,2,2-TRIFLUOROETHYL) ETHER Preparation Products And Raw materials |
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