ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyridine compound Chloropyridine 2-Amino-4-chloro-3-nitropyridine

2-Amino-4-chloro-3-nitropyridine

2-Amino-4-chloro-3-nitropyridine Basic information
Description Reference
Product Name:2-Amino-4-chloro-3-nitropyridine
Synonyms:2-AMINO-4-CHLORO-3-NITROPYRIDINE;4-Chloro-3-nitropyridin-2-amine;4-Chloro-3-nitro-pyridin-2-ylaMine;2-PyridinaMine, 4-chloro-3-nitro-;2-Amino-4-chloro-3-nitropyridine ISO 9001：2015 REACH;0/1/80
CAS:6980-08-1
MF:C5H4ClN3O2
MW:173.56
EINECS:
Product Categories:Heterocycle-Pyridine series;Amines;Nucleotides and Nucleosides;Pyridines;Aromatics;Heterocycles;API intermediates;Bases & Related Reagents;Nucleotides
Mol File:6980-08-1.mol
2-Amino-4-chloro-3-nitropyridine Structure
2-Amino-4-chloro-3-nitropyridine Chemical Properties
Melting point 174-176°C
Boiling point 329.0±37.0 °C(Predicted)
density 1.596±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility Soluble in dimethyl formamide, dimethyl sulfoxide, hot ethanol, ethyl acetate and hot methanol.
pka1.31±0.47(Predicted)
form Solid
color Yellow
Safety Information
HS Code 2933399990
MSDS Information
2-Amino-4-chloro-3-nitropyridine Usage And Synthesis
DescriptionIt is usually used as the intermediate or raw material in organic synthesis and pharmaceutical industry. Specifically, this chemical can act as the intermediate in the synthesis of 5-amino-azaoxindole derivatives.1 Moreover, this substance may be involved in the preparation of pharmaceutically active compounds that can be used in the treatment of proliferative disorders, as well as other diseases or conditions in which aurora kinase and/or FLT3 activity is implicated.2 In addition, this chemical has been demonstrated to function as the intermediate in the synthesis of 1-deaza-6-methylthiopurine ribonucleoside, which is proved to exhibit cytotoxicty.3 Besides, 2-amino-4-chloro-3-nitropyridine can be utilized to fabricate central nervous system (CNS) active compounds.4
Reference
  1. Tzvetkov, N. T.; Muller, C. E., Facile synthesis of 5-aminoand 7-amino-6-azaoxindole derivatives. Tetrahedron Lett. 2012, 53, 5597-5601.
  2. Julian Blagg; Bavetsias; Moore; Linardopoulos, pharmaceutically active compounds. US Patent US 9447092 B2 2016.
  3. JMontgomery, J. A.; Hewson, K., 1-DEAZA-6-METHYLTHIOPURINE RIBONUCLEOSIDE. J. Med. Chem. 1966, 9, 354-+.
  4. JHarry Louis Yale; Sheehan, J. T., CNS active compounds US Patent 4022897 1977.
Chemical PropertiesBright Yellow Needles
Uses2-Amino-4-chloro-3-nitropyridine is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.
(4-Chloro-3-nitro-pyridin-2-yl)-isopropyl-amine (4-Chloro-3-nitro-pyridin-2-yl)-[2-(4-methyl-piperazin-1-yl)-ethyl]-amine (4-Chloro-benzyl)-(4-chloro-3-nitro-pyridin-2-yl)-amine 2-Amino-3-nitropyridine (4-Chloro-3-nitro-pyridin-2-yl)-methyl-amine ALTRENOGEST 2,3,5,6-Tetrachloropyridine 3-Aminopyridine Glycine Difluorochloromethane (4-Chloro-3-nitro-pyridin-2-yl)-(2-piperidin-4-yl-ethyl)-amine Clopidol (4-Chloro-3-nitro-pyridin-2-yl)-(4-fluoro-benzyl)-amine 2-Aminopyridine 2-Amino-4-chloro-3-nitropyridine AMINO ACIDS (4-Chloro-3-nitro-pyridin-2-yl)-(2-fluoro-benzyl)-amine 4-Dimethylaminopyridine
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