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| Product Name: | KN-62 | | Synonyms: | 1-(N,O-BIS-(5-ISOQUINOLINESULFONYL)-*N-M ETHYL-L-TYR;KN-62 97%;KN-62, 99+%;4-((2S)-2-((5-isoquinolinylsulfonyl)methylamino)-3-oxo-3-(4-phenyl-1-piperazinyl)propyl)phenylisoquinolinesulfonicacid;1-(N,O-Bis-[5-isoquinolinesulfonyl]-N-methyl-L-tyrosyl)-4-phenylpiperazine, (S)-5-Isoquinolinesulfonic Acid 4-(2-[(5-Isoquinolinylsulfonyl)methylamino]- 3-oxo-3-[4-phenyl-1-piperazinyl]propyl)phenyl Ester,;5-Isoquinolinesulfonic acid, 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester;(s)-5-isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester;CS-756 | | CAS: | 127191-97-3 | | MF: | C38H35N5O6S2 | | MW: | 721.84 | | EINECS: | | | Product Categories: | Inhibitor;Protein Kinase;Protein Kinase Inhibitors and Activators | | Mol File: | 127191-97-3.mol |  |
| | KN-62 Chemical Properties |
| Melting point | 92-94°C | | Boiling point | 964.7±75.0 °C(Predicted) | | density | 1.388 | | storage temp. | -20°C | | solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.93 mg/mL | | form | solid | | pka | 4.07±0.13(Predicted) | | color | white | | CAS DataBase Reference | 127191-97-3(CAS DataBase Reference) |
| Safety Statements | 24/25 | | WGK Germany | 3 | | HS Code | 29339980 |
| | KN-62 Usage And Synthesis |
| Chemical Properties | Yellow Solid | | Uses | A specific inhibitor of Ca2+/Calmodulin-dependent protein kinase II | | Uses | selectively inhibits rat brain Ca2+/cadmodulin-dependent protein kinase II, | | Uses | It is used as a potent and selective inhibitor of CaMKII. KN-62 has demonstrated potent and selective inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII; Ki=0.9 ?M) which causes cells to arrest in the S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 ?M of KN-62 blocked CaMKII phosphorylation of III-AC, and inhibited hormone-stimulated Ca2+ oscillations. Additionally, KN-62 is a potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM). | | Definition | ChEBI: 5-isoquinolinesulfonic acid [4-[(2S)-2-[5-isoquinolinylsulfonyl(methyl)amino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl] ester is a member of piperazines. | | General Description | A cell-permeable, reversible, and selective inhibitor of CaM kinase II (Ki = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner. | | Biological Activity | Selective, cell-permeable inhibitor of CaM kinase II (IC 50 = 0.9 μ M). Binds directly to the calmodulin binding site of the enzyme. Potent non-competitive antagonist at the P2X 7 receptor (IC 50 = 15 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ . | | Biochem/physiol Actions | Selectively inhibits rat brain Ca2+/calmodulin-dependent protein kinase II. | | storage | -20°C (desiccate) |
| | KN-62 Preparation Products And Raw materials |
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