2-Bromoisobutyryl Bromide

2-Bromoisobutyryl Bromide Basic information

Product Name:	2-Bromoisobutyryl Bromide
Synonyms:	alpha-BroMoisobutyryl broMide 98%;2-Bromoisobutyryl bromide for synthesis;BROMOISOBUTYRYL(2-) BROMIDE;2-BROMOISOBUTYRYL BROMIDE;ALPHA-BROMOISOBUTYRYL BROMIDE;2-bromo-2-methyl-propanoylbromid;2-Bromoisobutanoyl bromide;Bromodimethylacetyl bromide
CAS:	20769-85-1
MF:	C4H6Br2O
MW:	229.9
EINECS:	244-017-3
Product Categories:	Acid Halides;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
Mol File:	20769-85-1.mol

2-Bromoisobutyryl Bromide Chemical Properties

Boiling point	162-164 °C(lit.)
density	1.86 g/mL at 20 °C
refractive index	n20/D 1.507(lit.)
Fp	>110°C
storage temp.	Store below +30°C.
solubility	Miscible with acetone and carbon disulfide.
form	Liquid
Specific Gravity	1.860 (20/4℃)
color	Clear light yellow to yellow
Water Solubility	reacts
Sensitive	Moisture Sensitive
BRN	1746128
Stability:	Stable, but may react with moisture. Incompatible with water, strong oxidizing agents, strong bases.
CAS DataBase Reference	20769-85-1(CAS DataBase Reference)
NIST Chemistry Reference	Propanoyl bromide, 2-bromo-2-methyl-(20769-85-1)
EPA Substance Registry System	Propanoyl bromide, 2-bromo-2-methyl- (20769-85-1)

Safety Information

Hazard Codes	C
Risk Statements	22-34
Safety Statements	26-36/37/39-45
RIDADR	UN 3265 8/PG 2
WGK Germany	3
TSCA	Yes
HazardClass	8
PackingGroup	II
HS Code	29159080

MSDS Information

Provider	Language
2-Bromo-2-methylpropionyl bromide	English
SigmaAldrich	English
ACROS	English
ALFA	English

2-Bromoisobutyryl Bromide Usage And Synthesis

Description	2-Bromoisobutyryl Bromide is a kind of bromide being useful in the chemical industry. It is used as an intermediate for the synthesis of pharmaceuticals, agrochemicals, dyes and other organic chemicals1. It can be used as atom transfer radical polymerization (ATRP) initiator for functionalization of hydroxyl groups present on the surface of graphene oxide; to form an N-protected halodienamide which provided fourand five-membered lactams in the presence of copper (I) and a tertiary amine; in preparation of polycaprolactone macroinitiator via reaction with oligomeric caprolactone dio and mesoporous silica nanoparticles with ATRP initiator anchored on the exterior surface2,3. As a initiator precursor, it can also be used for surface modification of Ethylene-vinyl alcohol (EVOH) copolymer films to grow surface-grafted poly-(acrylamide) chains.
Sources	http://www.chemicalland21.com/specialtychem/finechem/2-BROMOISOBUTYRYL%20BROMIDE.htm https://www.alfa.com/zh-cn/catalog/B24249/ https://www.sigmaaldrich.com/catalog/product/aldrich/252271?lang=en&region=US https://pubs.acs.org/doi/abs/10.1021/bk-2003-0854.ch025
Chemical Properties	colourless liquid
Uses	α-Bromoisobutyryl bromide has been used: as atom transfer radical polymerization (ATRP) initiator for functionalization of hydroxyl groups present on the surface of graphene oxide to form an N-protected halodienamide which provided four- and five-membered lactams in the presence of copper (I) and a tertiary amine in preparation of polycaprolactone macroinitiator via reaction with oligomeric caprolactone diol and mesoporous silica nanoparticles with ATRP initiator anchored on the exterior surface
Uses	2-Bromoisobutyryl bromide is used to prepare N-protected halodienamide, which provides four- and five-membered lactams in the presence of copper(I) and a tertiary amine. Further, it is used as atom transfer radical polymerization(ATRP) initiator for functionalization of hydroxyl groups present on the surface of graphene oxide. It is also used in preparation of polycaprolactone macroinitiators through reaction with oligomeric caprolactone diol and mesoporous silica nanoparticles with ATRP initiator anchored on the exterior surface.

2-Bromoisobutyryl Bromide Preparation Products And Raw materials

Raw materials

Phosphorus-->Isobutyric acid

Preparation Products

2-Bromo-2-methylpropionic acid-->Methyl 2-bromo-2-methylpropionate-->2-BROMO-2-METHYLPROPIOPHENONE-->2-bromo-1-(4-chlorophenyl)-2-methylpropan-1-one-->2-BROMO-2-METHYLPROPANAMIDE-->2-Bromo-2-methyl-N-(4-methylphenyl)propanamide-->Propanoic acid, 2-bromo-2-methyl-, 2-methoxyethyl ester-->2-Bromo-2,N,N-trimethyl-propionamide-->2-BROMO-2-METHYL-N-(1,3-THIAZOL-2-YL)PROPANAMIDE-->t-Butyl 2-bromo isobutyrate-->4-[4-(2-BROMO-2-METHYL-1-OXOPROPYL)PHENYL]-CYCLOHEXANEACETIC ACID ETHYL ESTER

2-Bromo-2-methylpropionic acid Propionyl bromide BUTYRYL BROMIDE Dimethyl sulfone Rocuronium bromide Bucladesine 2-Bromopropionyl bromide Daminozide Dibutyryl adenosine cyclophosphate calcium Sodium bromate Benzyl bromide Ethidium bromide Bromine Allyl bromide Chlorobromoisocyanurate 2-Bromoisobutyryl Bromide Scopolamine butylbromide Methyl bromide

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2-Bromoisobutyryl Bromide

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