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| | 4-Aminobenzohydrazide Basic information |
| | 4-Aminobenzohydrazide Chemical Properties |
| Melting point | 225-227 °C (lit.) | | Boiling point | 273.17°C (rough estimate) | | density | 1.2100 (rough estimate) | | refractive index | 1.5860 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMF: 10 mg/ml; DMSO: 14 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml | | form | Crystals or Powder | | pka | 13.05±0.10(Predicted) | | color | White or beige | | Water Solubility | Soluble in DMSO (10 mg/ml), dilute acids, and water (partly miscible). | | BRN | 639053 | | CAS DataBase Reference | 5351-17-7(CAS DataBase Reference) | | NIST Chemistry Reference | Benzoic acid, 4-amino-, hydrazide(5351-17-7) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | DG2580000 | | HazardClass | IRRITANT | | HS Code | 29280000 |
| | 4-Aminobenzohydrazide Usage And Synthesis |
| Description | 4-Aminobenzoic acid hydrazide (4-ABAH) is an irreversible inhibitor of myeloperoxidase (MPO; IC50 = 0.3 μM). It reduces the production of hypochlorous acid (HOCl) induced by opsonized zymosan or phorbol 12-myristate 13-acetate (PMA; ) in isolated human neutrophils with IC50 values of 16 and 2.2 μM, respectively. 4-ABAH inhibits PMA-induced formation of neutrophil extracellular traps (NETs) in the same cells. It reduces infarct volume and the severity of neurological deficits, as well as increases survival, in a mouse model of cerebral ischemia induced by transient middle cerebral artery occlusion (MCAO) when administered at a dose of 40 mg/kg twice per day. | | Chemical Properties | White or beige crystals or powder | | Uses | 4-Aminobenzhydrazide has an important role in the peroxidation activity of MPO. It is also used in enzyme preparations and in cell cultures. | | Uses | 4-Aminobenzoic hydrazide can be used as a reactant to synthesize:
- Acylhydrazone Schiff base ligand by condensation reaction with 2-acetylpyridine.
- Oligomeric transition metal complexes applicable in the fabrication of organic-inorganic hybrid devices with efficient electrical and photoelectrical properties.
- Oxovanadium(IV)-hydrazide complex as a potential radical scavenger.
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| | 4-Aminobenzohydrazide Preparation Products And Raw materials |
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