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| | Sodium Palmitate Basic information |
| | Sodium Palmitate Chemical Properties |
| | Sodium Palmitate Usage And Synthesis |
| Chemical Properties | white powder | | Chemical Properties | Sodium palmitate, white solid, soluble, froth or foam upon shaking the H2O solution (soap), formed by reaction of NaOH and palmitic acid (in alcoholic solution) and evaporating. Used as a source of palmitate. | | Uses | Sodium palmitate (PA) has been used:
- to induce inflammation and thrombosis pathway in murine macrophage cell line RAW 264.7 cell line by activating reactive oxygen species (ROS) production, Janus-kinase (JNK) signalling and release of histone H3 by western blotting and cell viability by MTT assay
- to induce lipogenesis in AML12 cells and primary hepatocytes to analyse the effect of irisin on PA induced lipogenesis and related signal pathways by western blot analysis and quantitative PCR analysis
- as a component in free fatty acid mixture to induce cellular steatosis in HepG2 cell lines and determination of lipid accumulation by Oil-Red-O staining
| | Uses | Sodium Palmitate is the sodium salt of palmitic acid. It functions as a binder, emulsifier, and anticaking agent. | | Uses | Polymerization catalyst for synthetic rubbers,
laundry and toilet soaps, detergents, cosmetics,
pharmaceuticals, printing inks, and as an emulsi-
fier.
| | Hazard | A poison. Combustible. | | Biochem/physiol Actions | Sodium palmitate is the sodium salt of palmitic acid, a component in hard soaps. Palmitic acid is a common saturated fatty acid and produced during fatty acid synthesis. Sodium palmitate enhances lipogenesis, cellular steatosis in various cell lines. Palmitate induces cell death in human epidermal growth factor receptor 2 (HER2)/neu-positive cells and breast cancer cell lines like MCF-7 due to enhanced fatty acid accumulation. Sodium palmitate induces lipoapoptosis in L02 and HepG2 liver cells by inducing glycogen synthase kinase-3β (GSK3β) expression. | | Safety Profile | A poison by intravenous route. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. | | Purification Methods | It crystallises from EtOH and is dried in an oven. [Beilstein 2 IV 1157.] |
| | Sodium Palmitate Preparation Products And Raw materials |
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