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2'-O-Methyluridine

2'-O-Methyluridine Basic information
Product Name:2'-O-Methyluridine
Synonyms:2'-O-METHYLURIDINE (CHIRAL);2''-O-METHYLURIDINE CRYSTALLINE;1-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]pyrimidine-2,4-quinone;1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxy-oxolan-2-yl]pyrimidine-2,4-dione;1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione;2'-O-METHYLURIDINE;2-Methyoxy uridine;1-[(2S,3S,4R,5S)-4-hydroxy-5-(hydroxyMethyl)-3-Methoxyoxolan-2-yl]-1,2,3,4-tetrahydropyriMidine-2,4-dione
CAS:2140-76-3
MF:C10H14N2O6
MW:258.23
EINECS:2017-001-1
Product Categories:pyrimidine;Heterocycle-Pyrimidine series;Bases & Related Reagents;Carbohydrates & Derivatives;Heterocycles;Nucleotides;Pharmaceutical;2140-76-3;Nucleosides
Mol File:2140-76-3.mol
2'-O-Methyluridine Structure
2'-O-Methyluridine Chemical Properties
Melting point 154-156°C
density 1.53±0.1 g/cm3(Predicted)
storage temp. Inert atmosphere,2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
pka9.39±0.10(Predicted)
form Powder
color White to Off-white
λmax261nm(MeOH)(lit.)
CAS DataBase Reference2140-76-3(CAS DataBase Reference)
Safety Information
Hazard Codes T+
Risk Statements 26/27/28
Safety Statements 24/25
HS Code 29389090
MSDS Information
2'-O-Methyluridine Usage And Synthesis
Description2'-O-Methyluridine is an analog of uridine and has been shown to have antiviral and anticancer properties. 2'-O-Methyluridine inhibits protein synthesis by competing with uridine for the active site of the enzyme ribonucleotide reductase, which converts ribonucleotides to dNMPs. This compound also inhibits RNA synthesis by disrupting the pairing of adenine and cytosine residues in RNA strands.
Chemical PropertiesWhite Solid
UsesUridine analog. 2'-O-Methyluridine is used for preparation of antiviral nucleoside derivatives as inhibitors of subgenomic hepatitis C virus RNA replication.
UsesUridine analog. Used for preparation of antiviral nucleoside derivatives as inhibitors of subgenomic hepatitis C virus RNA replication.
DefinitionChEBI: A methyluridine that consists of uridine bearing a single methyl substituent located at position O-2' on the ribose ring.
2'-O-Methyluridine Preparation Products And Raw materials
Raw materialsUridine, 2'-O-methyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-
Preparation Products3-METHYL URIDINE
5-BROMO-2',3',5'-TRI-O-ACETYLURIDINE 5'-O-(DMT)-5-FLUORO-2'-O-METHYLURIDINE 5-METHYL-2'-O-METHYLURIDINE 5'-O-(DIMETHOXYTRITYL)-2'-O-METHYL-5-METHYLURIDINE 2',3',5'-Tri-O-acetyluridine Methyluridine 2'-O-METHYLURIDINE-5'-TRIPHOSPHATE LITHIUM SALT 3',5'-DI-O-BENZOYL-5-FLUORO-2'-O-METHYLURIDINE 5-Chloro-5'-deoxy-2'-O,3'-O-isopropylidene-5'-methyluridine 2',3',5'-TRI-O-BENZOYLURIDINE 2',3'-DI-O-BENZOYLURIDINE uridine diphosphate glucose {= UDP-glucose} DMT-2μ-O-Me-rU amidite 2'-O-METHYLURIDINE-5'-DIPHOSPHATE SODIUM SALT 2'-O-METHYL-5-METHYLURIDINE-5'-TRIPHOSPHATE LITHIUM SALT 3',5'-DI-O-ACETYL-5-FLUORO-2'-O-METHYLURIDINE 5'-O-(DMT)-5-IODO-2'-O-METHYLURIDINE 2'-O-MOE-5-METHYLURIDINE
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