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| | Androstenedione Chemical Properties |
| Melting point | 170-171 °C(lit.) | | alpha | D30 +199° (in chloroform) | | Boiling point | 368.77°C (rough estimate) | | density | 1.0655 (rough estimate) | | refractive index | 1.4709 (estimate) | | Fp | 2℃ | | storage temp. | Controlled Substance, -20°C Freezer | | solubility | Chloroform (Slightly), Ethanol (Slightly, Sonicated), Methanol (Sparingly) | | form | Solid | | color | Dimorphous: Needles from acetone, or crystalsfrom hexane | | Water Solubility | 57.28mg/L(25 ºC) | | Merck | 13,643 | | InChIKey | AEMFNILZOJDQLW-QAGGRKNESA-N | | CAS DataBase Reference | 63-05-8(CAS DataBase Reference) | | NIST Chemistry Reference | Androst-4-ene-3,17-dione(63-05-8) | | EPA Substance Registry System | 4-Androstenedione (63-05-8) |
| | Androstenedione Usage And Synthesis |
| Biological Metabolism | The in vitro perfusion of the human placental lobule with 7-ethoxycoumarin gives 7-hydroxycoumarin, and perfusion with androstenedione gives the conversion products, estrone, estradiol, and testosterone. The human placenta has only a limited capacity for the metabolism of xenobiotics.
| | Description | Androstenedione (CRM) (Item No. ISO60161) is a certified reference material categorized as an anabolic androgenic steroid. Androstenedione is a precursor of testosterone (Item Nos. ISO60154 | ISO00154 | 15645) and estrone . Androstenedione is regulated as a Schedule III compound in the United States. Androstenedione (CRM) (Item No. ISO60161) is provided as a DEA exempt preparation. This product is intended for research and forensic applications. | | Chemical Properties | White to Off-White Solid | | Uses | Testosterone precursor and metabolite with androgenic activity.
Controlled substance (anabolic sterid) | | Definition | ChEBI: A 3-oxo Delta4-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17. It is a steroid hormone synthesized in the adrenal glands and gonads. | | Safety Profile | An experimental teratogen. Otherexperimental reproductive effects. Questionablecarcinogen with experimental tumorigenic data. Whenheated to decomposition it emits acrid smoke andirritating fumes. | | Purification Methods | Crystallise the dione from hexane. It is soluble in *C6H6, CHCl3 and EtOH. It has max at 239nm. It is a precursor of estrone or testosterone and has androgenic activity. [Ruzicka & Wettstein Helv Chim Acta 18 980 1935, Beilstein 7 III 3636, 7 IV 2381.] |
| | Androstenedione Preparation Products And Raw materials |
| Raw materials | beta-Sitosterol-->3-keto-23,24-bisnorchol-4-en-22-ol-->CAMPESTEROL-->Cholesterol-->(8S,9R,10S,13S,14S,17S)-9,17-dihydroxy-10,13-dimethyl-2,6,7,8,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-one | | Preparation Products | Spironolactone-->5B-ANDROSTANE-3,17-DIONE-->Androsta-1,4-diene-3,17-dione-->Testosterone undecanoate-->Androst-3-en-17-one,(5)-->5α-Androstane-3,6,17-trione-->11α-Hydroxyandrost-4-ene-317-dione-->Methyl 3-oxo-4-androstene-17beta-carboxylate-->6-METHYLENEANDROST-4-ENE-3,17-DIONE |
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