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| | 1,2,4-Benzenetriol Basic information |
| Product Name: | 1,2,4-Benzenetriol | | Synonyms: | OXYHYDROQUINONE;1,2,4-BENZENETRIOL;1,3,4-Benzenetriol;1,3,4-Trihydroxybenzene;2,5-Dihydroxyphenol;2-Hydroxy-1,4-hydroquinone;Hydroquinone, hydroxy-;hydroxy-hydroquinon | | CAS: | 533-73-3 | | MF: | C6H6O3 | | MW: | 126.11 | | EINECS: | 208-575-1 | | Product Categories: | Aromatic Hydrocarbons (substituted) & Derivatives;Aromatics Compounds;Aromatics;Metabolites & Impurities;bc0001 | | Mol File: | 533-73-3.mol |  |
| | 1,2,4-Benzenetriol Chemical Properties |
| Melting point | 140 °C (subl.) (lit.) | | Boiling point | 194.21°C (rough estimate) | | density | 1.45 g/cm3 (20℃) | | refractive index | 1.5627 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMSO (Sparingly), Methanol (Slightly) | | form | Solid | | pka | 9.58±0.10(Predicted) | | color | Plates from Et2O | | Water Solubility | freely soluble | | Sensitive | Air Sensitive | | Merck | 14,1073 | | BRN | 2042863 | | Stability: | Light Sensitive, Moisture Sensitive | | CAS DataBase Reference | 533-73-3(CAS DataBase Reference) | | NIST Chemistry Reference | 1,2,4-Benzenetriol(533-73-3) | | EPA Substance Registry System | 1,2,4-Benzenetriol (533-73-3) |
| | 1,2,4-Benzenetriol Usage And Synthesis |
| Chemical Properties | Gray powder | | Uses | 1,2,4-Trihydroxybenzene is an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.It is used as a metabolite of benzene. | | Definition | ChEBI: Benzene-1,2,4-triol is a benzenetriol carrying hydroxy groups at positions 1, 2 and 4. It has a role as a mouse metabolite. | | General Description | 1,2,4-Benzenetriol is also known as hydroxyhydroquinone. It is an intermediary metabolite of benzene that is present in roasted coffee beans. It is mutagenic and it causes cleaving of DNA single strands by the generation of reactive oxygen species. | | Safety Profile | Poison by
subcutaneous and intraperitoneal routes.
Human mutation data reported. When
heated to decomposition it emits acrid
smoke and irritating fumes. | | Purification Methods | Crystallise the triol from Et2O or Et2O/EtOH, and dry it in a vacuum. The picrate forms orange-red needles m 96o. [Beilstein 6 H 1087, 6 I 541, 6 II 1071, 6 III 6276.] |
| | 1,2,4-Benzenetriol Preparation Products And Raw materials |
| Raw materials | 1,4-Benzoquinone-->1,2,4-Triacetoxybenzene | | Preparation Products | 2,4,5-TRIHYDROXYBENZALDEHYDE-->2,4,5-TRIHYDROXYBENZOIC ACID-->6,7-Dihydroxy-4-propyl-2H-chromen-2-one-->9-METHYL-2,3,7-TRIHYDROXY-6-FLUORONE HEMISULFATE |
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